ArticleAge and ageing2021
Long-term effect of a 24-week multicomponent intervention on physical performance and frailty in community-dwelling older adults.
Article in Age and ageing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Effects of multidomain interventions on health outcomes in older adults: A systematic review and meta-analysis.The journal of nutrition, health & aging · 2026Pooled it
- The effectiveness of alternatives to residential care for older people with on-going health and social care needs: a systematic review.BMC geriatrics · 2026Pooled it
- Cluster randomized trial of reablement strategies targeting sarcopenia (ReStart-S) in long-term care settings.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Trial
- Relative impact of multidomain lifestyle interventions on deficit accumulation frailty over 24 months in the U.S. POINTER trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Trial
- Impact of a nurse-led multidomain intervention on intrinsic capacity among community-dwelling older adults in China: a cluster randomized trial.BMC public health · 2025Trial
- Associations Between Deficit Accumulation Frailty and Baseline Markers of Lifestyle in the U.S. POINTER Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Trial
- The Effectiveness of Frailty Intervention for Older Patients with Frailty during Hospitalization.The journal of nutrition, health & aging · 2023Trial
- Twelve-Week Group-Based Exercise and Nutrition Programs: Feasibility and Preliminary Health Improvements in Disabilities.Geriatrics & gerontology international · 2026Article
- Sarcopenia: From Global Consensus to Korean Implementation - A Narrative Review and Standpoint.Annals of geriatric medicine and research · 2026Review
- Molecular pathways linking chronic psychological stress to accelerated aging: mechanisms and interventions.Frontiers in aging · 2026Review
- Long-Term Health and Cost Outcomes of a 24-Week Multicomponent Frailty Intervention in Older Adults.JAMA network open · 2025Article
- What Do We Know About Prevention of Frailty in Women?American journal of lifestyle medicine · 2025Review
- Unsupervised Frailty Intervention by Digitalized Exercise Coaching: A Feasibility Study.Sensors (Basel, Switzerland) · 2025Article
- Effect of a multicomponent intervention on institutionalization-free survival in older adults with sarcopenia: aFrontiers in medicine · 2025Article
- Development of a Complex Intervention for Promoting Participation in Resistance Exercise Among Community-Dwelling Frail Older Adults in China: A Multimethod Qualitative Study.Innovation in aging · 2025Article
- Cross-sectional and longitudinal associations among healthcare costs and deficit accumulation.Journal of the American Geriatrics Society · 2024Article
- Clinical Trials for Special Populations: Children, Older Adults, and Rare Diseases.Mayo Clinic proceedings · 2024Review
- Sarcopenia as the Mobility Phenotype of Aging: Clinical Implications.Journal of bone metabolism · 2024Article
- Multisystem physiological perspective of human frailty and its modulation by physical activity.Physiological reviews · 2023Review
- Korean Working Group on Sarcopenia Guideline: Expert Consensus on Sarcopenia Screening and Diagnosis by the Korean Society of Sarcopenia, the Korean Society for Bone and Mineral Research, and the Korean Geriatrics Society.Annals of geriatric medicine and research · 2023Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
introductionMulticomponent interventions improve physical function and frailty in older adults, but their long-term benefit remains uncertain.
methodsThis prospective non-randomised study was conducted in 383 older Koreans (mean age, 76.8 years; female 72.3%) who were living alone or receiving medical aid. Of these, 187 individuals chose to receive a 24-week intervention that consisted of group exercise, nutritional supplements, depression management, deprescribing and home hazard reduction. The remaining 196 individuals received usual care. We compared the short physical performance battery (SPPB) score (0-12 points), frailty phenotype scale (0-5 points) and deficit-accumulation frailty index (0-1) at baseline, 6, 18 and 30 months.
resultsAfter 1:1 propensity score matching (n = 117 per group), the mean SPPB scores for the intervention and comparison groups were 7.6 versus 7.6 at baseline, 10.7 versus 7.1 at 6 months (mean difference, 3.5; 95% confidence interval [CI], 2.8-4.2), 9.1 versus 7.8 at 18 months (1.3; 95% CI, 0.6-2.0) and 8.6 versus 7.5 at 30 months (1.1; 95% CI, 0.4-1.8). The intervention group had lower frailty phenotype scale (1.1 versus 1.8; difference, -0.7; 95% CI -1.0 to -0.3) and frailty index (0.22 versus 0.27; difference, -0.04; -0.06 to -0.02) at 6 months, but similar scores at 18 and 30 months. The 30-month mean institutionalisation-free survival time was 28.5 months in the intervention group versus 23.3 months in the comparison group (difference, 5.2 months; 95% CI, 3.1-7.4).
conclusionsThe 24-week multicomponent intervention showed sustained improvement in physical function, temporary reduction in frailty and longer institutionalisation-free survival over 30 months.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.