Evidence map›Paper›PMID 34351073›Full record

ArticleMolecular ecology resources2022

Pseudoreplication in genomic-scale data sets.

Robin S Waples, Ryan K Waples, Eric J Ward

Abstract read
In one paragraph

Article in Molecular ecology resources, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Combining Multiple Genetic Estimates of NMolecular ecology resources · 2026
    Article
  2. Review
  3. Maximising the Potential of TemporalMolecular ecology resources · 2025
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  4. Article
  5. Review
  6. Article
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  9. Unraveling the Complexity of theEvolutionary applications · 2024
    Review
  10. Article
  11. TheEvolutionary applications · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Robin S WaplesNOAA Fisheries, Northwest Fisheries Science Center, Seattle, WA, USA.ORCID https://orcid.org/0000-0003-3362-7590
Ryan K WaplesDepartment of Biology, Section for Computational and RNA Biology, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-0526-6425
Eric J WardNOAA Fisheries, Northwest Fisheries Science Center, Seattle, WA, USA.ORCID https://orcid.org/0000-0002-4359-0296

Funding

INTERDISCIPLINARY TRAINING IN GENOMIC SCIENCEST32HG000035 · NHGRI · UNIVERSITY OF WASHINGTON · PI Bruce Colston Trapnell · 1995 to 2026
$24.2M
NHGRI NIH HHS T32 HG000035
6 · The paper itself

Abstract

In genomic-scale data sets, loci are closely packed within chromosomes and hence provide correlated information. Averaging across loci as if they were independent creates pseudoreplication, which reduces the effective degrees of freedom (df') compared to the nominal degrees of freedom, df. This issue has been known for some time, but consequences have not been systematically quantified across the entire genome. Here, we measured pseudoreplication (quantified by the ratio df'/df) for a common metric of genetic differentiation (F

Indexed as

GenomicsModels, GeneticGenome SizeLinkage DisequilibriumPedigreePopulation Densitydegrees of freedomFSTgenome sizejackknife variancelinkage disequilibriumNesimulations

Identifiers

PMID34351073
PMCPMC9415146

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.