Evidence map›Paper›PMID 34351035›Full record

ArticleDiabetes, obesity & metabolism2021

Effectiveness of a ketogenic diet and virtual coaching intervention for patients with diabetes: A difference-in-differences analysis.

Kiersten L Strombotne, Jessica Lum, Nambi J Ndugga, Anne E Utech, Steven D Pizer, Austin B Frakt, Paul R Conlin

Open access · greenAbstract read
In one paragraph

Article in Diabetes, obesity & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Observational
  4. Article
  5. Low-Carbohydrate and Ketogenic Dietary Patterns for Type 2 Diabetes Management.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2024
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Kiersten L StrombotneDepartment of Health Law, Policy and Management, Boston University of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-7457-7211
Jessica LumVA Boston Healthcare System, Boston, Massachusetts, USA.
Nambi J NduggaDepartment of Health Law, Policy and Management, Boston University of Public Health, Boston, Massachusetts, USA.
Anne E UtechVeterans Health Administration, Department of Veterans Affairs, Washington, District of Columbia, USA.
Steven D PizerDepartment of Health Law, Policy and Management, Boston University of Public Health, Boston, Massachusetts, USA.
Austin B FraktDepartment of Health Law, Policy and Management, Boston University of Public Health, Boston, Massachusetts, USA.
Paul R ConlinVA Boston Healthcare System, Boston, Massachusetts, USA.
Boston University · USHarvard University · USUnited States Department of Veterans Affairs · USVA Boston Healthcare System · US

Funding

Hemoglobin A1C Variability as a Risk Factor for Diabetes ComplicationsR01DK114098 · NIDDK · HARVARD MEDICAL SCHOOL · PI CONLIN, PAUL R · 2019 to 2022
$2.3M
NIDDK NIH HHS R01 DK114098
6 · The paper itself

Abstract

aimTo test the effectiveness of a ketogenic diet and virtual coaching intervention in controlling markers of diabetes care and healthcare utilization. MATERIALS AND

methodsUsing a difference-in-differences analysis with a waiting list control group-a quasi-experimental methodology-we estimated the 5-month change in HbA1c, body mass index, blood pressure, prescription medication use and costs, as well as healthcare utilization. The analysis included 590 patients with diabetes who were also overweight or obese, and who regularly utilize the Veterans Health Administration (VA) for healthcare. We used data from VA electronic health records from 2018 to 2020.

resultsThe ketogenic diet and virtual coaching intervention was associated with significant reductions in HbA1c (-0.69 [95% CI -1.02, -0.36]), diabetes medication fills (-0.38, [-0.49, -0.26]), body mass index (-1.07, [-1.95, -0.19]), diastolic blood pressure levels (-1.43, [-2.72, -0.14]), outpatient visits (-0.36, [-0.70, -0.02]) and prescription drug costs (-34.54 [-48.56, -20.53]). We found no significant change in emergency department visits (-0.02 [-0.05, 0.01]) or inpatient admissions (-0.01 [-0.02, 0.01]).

conclusionsThis real-world assessment of a virtual coaching and diet programme shows that such an intervention offers short-term benefits on markers of diabetes care and healthcare utilization in patients with diabetes.

Indexed as

Diabetes MellitusDiabetes Mellitus, Type 2Diet, KetogenicMentoringHumansObesityOverweightdietary interventionhealth economicstype 2 diabetesweight control

Identifiers

PMID34351035
PMCPMC8789005
OpenAlexW3189078976

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.