Evidence map›Paper›PMID 34350994›Full record

ArticleThe Journal of comparative neurology2022

The RNA-binding protein and stress granule component ATAXIN-2 is expressed in mouse and human tissues associated with glaucoma pathogenesis.

Chad A Sundberg, Monika Lakk, Sharan Paul, Karla P Figueroa, Daniel R Scoles, Stefan M Pulst, David Križaj

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of comparative neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Chad A SundbergDepartment of Ophthalmology & Visual Sciences, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0002-4344-6147
Monika LakkDepartment of Ophthalmology & Visual Sciences, University of Utah, Salt Lake City, Utah, USA.
Sharan PaulDepartment of Neurology, University of Utah, Salt Lake City, Utah, USA.
Karla P FigueroaDepartment of Neurology, University of Utah, Salt Lake City, Utah, USA.
Daniel R ScolesDepartment of Neurology, University of Utah, Salt Lake City, Utah, USA.
Stefan M PulstDepartment of Neurology, University of Utah, Salt Lake City, Utah, USA.
David KrižajDepartment of Ophthalmology & Visual Sciences, University of Utah, Salt Lake City, Utah, USA.
University of Utah · US

Funding

University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI PAUL STEVEN BERNSTEIN · 2005 to 2026
$14.6M
Spinocerebellar Ataxia Type 2 Gene and Gene ProductR37NS033123 · NINDS · UNIVERSITY OF UTAH · PI PULST, STEFAN M. · 2014 to 2020
$3.6M
Replacement of the Flexcell Tension systemR01EY027920 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI DAVID KRIZAJ · 2017 to 2026
$3.5M
RNA Granules in Cerebellar NeurodegenerationR01NS097903 · NINDS · UNIVERSITY OF UTAH · PI SCOLES, DANIEL R · 2017 to 2021
$2.7M
Antisense Oligonucleotides for treating Spinocerebellar Ataxia Type 2U01NS103883 · NINDS · UNIVERSITY OF UTAH · PI PULST, STEFAN M., SCOLES, DANIEL R · 2018 to 2020
$1.9M
Cellular and Molecular Mechanisms that Contribute to Pressure-Induced Retinal Inflammation and PathologyR01EY031817 · NEI · UNIVERSITY OF UTAH · PI KRIZAJ, DAVID · 2021 to 2024
$1.5M
Spinocerebellar Ataxia Type 2 Gene and Gene ProductR56NS033123 · NINDS · UNIVERSITY OF UTAH · PI PULST, STEFAN M. · 2013 to 2013
$473k
Characterization of ATXN2 as a target for ALS in SCA2 motor neuronsR21NS103009 · NINDS · UNIVERSITY OF UTAH · PI PULST, STEFAN M., SCOLES, DANIEL R · 2018 to 2019
$419k
MOLECULAR ANALYSIS OF TRIGEMINAL AXON GUIDANCEF32NS010300 · NINDS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI O'CONNOR, ROBERT J · 1996 to 1998
–
NEI NIH HHS P30 EY014800NEI NIH HHS R01 EY027920NEI NIH HHS R01EY027920, R01EY031817, P30EY014800NEI NIH HHS R01 EY031817NINDS NIH HHS F32 NS010300NINDS NIH HHS R01 NS097903NINDS NIH HHS R01NS097903NINDS NIH HHS R21NS10300NINDS NIH HHS R21 NS103009NINDS NIH HHS R37 NS033123NINDS NIH HHS R37NS033123NINDS NIH HHS R56 NS033123NINDS NIH HHS R56NS33123NINDS NIH HHS U01 NS103883NINDS NIH HHS U01NS103883
6 · The paper itself

Abstract

Polyglutamine repeat expansions in the Ataxin-2 (ATXN2) gene were first implicated in Spinocerebellar Ataxia Type 2, a disease associated with degeneration of motor neurons and Purkinje cells. Recent studies linked single nucleotide polymorphisms in the gene to elevated intraocular pressure in primary open angle glaucoma (POAG); yet, the localization of ATXN2 across glaucoma-relevant tissues of the vertebrate eye has not been thoroughly examined. This study characterizes ATXN2 expression in the mouse and human retina, and anterior eye, using an antibody validated in ATXN2

Indexed as

Amacrine CellsAnimalsAtaxin-2DendritesDisease Models, AnimalGlaucoma, Open-AngleHumansMicePolymorphism, Single NucleotideRetinaRetinal Ganglion CellsStress GranulesAtaxin-2ATXN2 protein, humanAtxn2 protein, mouseATXN2autophagyprimary open angle glaucomaretinal ganglion cellsRNA-binding proteinSCA2stress granules

Identifiers

PMID34350994
PMCPMC8716417
OpenAlexW3188835964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.