Evidence map›Paper›PMID 34350866›Full record

ArticleCerebrovascular diseases extra2021

Warning Signs in the Era of Unruptured Intracranial Aneurysms: Report on 2 Cases of Fatal Aneurysmal Hemorrhage.

Katarzyna Wójtowicz, Przemysław Kunert, Łukasz Przepiórka, Andrzej Marchel

Abstract readCase Reports
In one paragraph

Article in Cerebrovascular diseases extra, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katarzyna WójtowiczDepartment of Neurosurgery, Medical University of Warsaw, Warsaw, Poland.
Przemysław KunertDepartment of Neurosurgery, Medical University of Warsaw, Warsaw, Poland.
Łukasz PrzepiórkaDepartment of Neurosurgery, Medical University of Warsaw, Warsaw, Poland.
Andrzej MarchelDepartment of Neurosurgery, Medical University of Warsaw, Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe timing of treatment remains unresolved for patients with unruptured intracranial aneurysms (UIAs) and headaches, particularly when the pain is short term, localized, and related to the aneurysm site. We lack evidence to support the notion that when a headache accompanies an aneurysm, it elevates the risk of rupture.

resultsWe describe 2 cases of fatal subarachnoid hemorrhage in patients with a history of headache and known aneurysms. Both of these patients had good indications for treatment: a young age and an aneurysm >7 mm, and both were qualified for elective surgery. However, both patients died of fatal aneurysm ruptures before the planned surgery.

conclusionThese cases suggested that treatment should be started as soon as possible, when a UIA is diagnosed based on a short-term period of severe headaches or when a UIA is observed and then severe headaches appear. There is no straightforward guideline for treatment timing in these patients. However, in this era of UIAs, the significance of sentinel headaches should be reevaluated. Given the incidence of headaches in the general population and the very low risk of aneurysm rupture, there may be a tendency to neglect the role of headache as a possible warning sign.

Indexed as

AdultAneurysm, RupturedDisease ProgressionFatal OutcomeFemaleHeadacheHumansIntracranial AneurysmRisk FactorsSubarachnoid HemorrhageTime-to-TreatmentSubarachnoid hemorrhageUnruptured intracranial aneurysmWarning signs

Identifiers

PMID34350866
PMCPMC8647099

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.