ArticleeLife2021
Adipocyte NR1D1 dictates adipose tissue expansion during obesity.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 59 citations in OpenAlex.
- Circadian mechanisms in heart failure: Cell-specific regulation and chrono-medicine.Cell insight · 2026Review
- Discovery of circadian clock activators with anti-obesity efficacy via suppression of adipocyte development and hypertrophy.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Chemical biology approaches to study and target circadian clocks and their components.FEBS letters · 2026Review
- Novel role of NR1D1 and SLC7A5 in gestational diabetes mellitus: regulation of polyamine metabolism.Journal of diabetes and metabolic disorders · 2025Article
- Molecular responses in abdominal subcutaneous adipose tissue after a session of endurance exercise: effects of exercise intensity.The Journal of physiology · 2025Article
- Time to Reset: The Interplay Between Circadian Rhythms and Redox Homeostasis in Skeletal Muscle Ageing and Systemic Health.Antioxidants (Basel, Switzerland) · 2025Review
- Article
- A Developmental Gene Expression Atlas Reveals Novel Biological Basis of Complex Phenotypes in Sheep.Genomics, proteomics & bioinformatics · 2025Article
- Acute session of three endurance exercise intensities alters subcutaneous adipose tissue transcriptome in regular exercisers.bioRxiv : the preprint server for biology · 2025Article
- Article
- Circadian Disruption and the Risk of Developing Obesity.Current obesity reports · 2025Review
- Galactose-Induced Cataracts in Rats: A Machine Learning Analysis.International journal of medical sciences · 2025Article
- Years of endurance exercise training remodel abdominal subcutaneous adipose tissue in adults with overweight or obesity.Nature metabolism · 2024Article
- Excessive fat expenditure in MCT-induced heart failure rats is associated with BMAL1/REV-ERBα circadian rhythmic loop disruption.Scientific reports · 2024Article
- Whole-body deletion of Endospanin 1 protects from obesity-associated deleterious metabolic alterations.JCI insight · 2024Article
- Review
- Inference of differential key regulatory networks and mechanistic drug repurposing candidates from scRNA-seq data with SCANet.Bioinformatics (Oxford, England) · 2023Article
- Circadian mechanisms in adipose tissue bioenergetics and plasticity.Genes & development · 2023Review
- The REV-ERB Nuclear Receptors: Timekeepers for the Core Clock Period and Metabolism.Endocrinology · 2023Review
- Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation.Nature communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 2 countries.
Ann Louise Hunter *Centre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.ORCID 0000-0002-3874-4852
Charlotte E Pelekanou *Centre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Nichola J BarronCentre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Rebecca C NortheastCentre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.ORCID 0000-0002-3121-2802
Magdalena GrudzienCentre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Antony D AdamsonCentre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Polly DowntonCentre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.ORCID 0000-0002-1617-6153
Thomas CornfieldOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom.
Peter S CunninghamCentre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Jean-Noel BillaudDigital Insights, Qiagen, Redwood City, United States.
Leanne HodsonOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom.
Andrew Si LoudonCentre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Richard D UnwinStoller Biomarker Discovery Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Mudassar IqbalDivision of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
David W RayOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom.
David A BechtoldCentre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.ORCID 0000-0001-8676-8704
University of Manchester · GBJohn Radcliffe Hospital · GBManchester Academic Health Science Centre · GBQiagen (United States) · US
Funding
Biotechnology and Biological Sciences Research Council BB/I018654/1Medical Research Council MR/M008908/1Medical Research Council MR/N021479/1Medical Research Council MR/P00279X/1Medical Research Council MR/P011853/1Medical Research Council MR/P023576/1Medical Research Council MR/P023576/2Wellcome Trust 107849/Z/15/ZWellcome Trust 107851/Z/15/Z
Abstract
The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with global
Indexed as
AdipocytesAdipose TissueAnimalsEnergy MetabolismGene DeletionLipid MetabolismMaleMiceNuclear Receptor Subfamily 1, Group D, Member 1ObesityNr1d1 protein, mouseNuclear Receptor Subfamily 1, Group D, Member 1adiposecell biologycircadian clockenergy metabolismmedicinemouseobesityRev-erb-alphaRev-erbα
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.