Evidence map›Paper›PMID 34350826›Full record

ArticleeLife2021

Precise optical control of gene expression in

Lloyd Davis, Inja Radman, Angeliki Goutou, Ailish Tynan, Kieran Baxter, Zhiyan Xi, Jack M O'Shea, Jason W Chin, Sebastian Greiss

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. A lateralized sensory signaling pathway mediates context-dependent olfactory plasticity inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
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  9. Article
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  12. Tuning tRNAs for improved translation.Frontiers in genetics · 2024
    Review
  13. Article
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  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Lloyd DavisCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Inja Radman *Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
Angeliki Goutou *Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Ailish TynanCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Kieran BaxterCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Zhiyan XiCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Jack M O'SheaCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.ORCID https://orcid.org/0000-0002-9694-7340
Jason W ChinMedical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
Sebastian GreissCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.ORCID https://orcid.org/0000-0001-9130-0831
Discovery Centre · CAMRC Laboratory of Molecular Biology · GB

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Medical Research Council MC_U105181009Medical Research Council MC_UP_A024_1008NIH HHS P40 OD010440Wellcome Trust
6 · The paper itself

Abstract

Synthetic strategies for optically controlling gene expression may enable the precise spatiotemporal control of genes in any combination of cells that cannot be targeted with specific promoters. We develop an improved genetic code expansion system in

Indexed as

AnimalsBehavior, AnimalCaenorhabditis elegansGene ExpressionGenetic CodeGenetic EngineeringIntegrasesNeuronsOptogeneticsTouch PerceptionCre recombinaseIntegrasesbiochemistryC. eleganschemical biologyCre recombinasegenetic code expansionneurosciencenon canonical amino acidsoptogeneticsphoto-caged amino acid

Identifiers

PMID34350826
PMCPMC8448529
OpenAlexW3193267775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.