Evidence map›Paper›PMID 34350768›Full record

ArticleBioTechniques2021

Screening for androgen agonists using autonomously bioluminescent HEK293 reporter cells.

Tingting Xu, Madison Gilliam, Gary Sayler, Steven Ripp, Dan Close

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioTechniques, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Tingting XuCenter for Environmental Biotechnology, The University of Tennessee, Knoxville, TN 37996, USA.
Madison GilliamThe Department of Biology, Maryville College, Maryville, TN 37804, USA.
Gary SaylerCenter for Environmental Biotechnology, The University of Tennessee, Knoxville, TN 37996, USA.
Steven RippCenter for Environmental Biotechnology, The University of Tennessee, Knoxville, TN 37996, USA.
Dan Close490 BioTech Inc., 2450 EJ Chapman Drive, Knoxville, TN 37996, USA.
490 BioTech (United States) · USMaryville College · USUniversity of Tennessee at Knoxville · US

Funding

Expressing bacterial bioluminescence in human cell lines: Engineering autobioluminescent reporter cells to screen for endocrine disruptor chemicalsR44ES022567 · NIEHS · 490 BIOTECH, INC. · PI MORRISON, DAN · 2015 to 2016
$996k
UT Summer Undergraduate Research Experiences in the Environmental Health SciencesR25ES028976 · NIEHS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI LOEFFLER, FRANK E., MILLET, LARRY J. · 2018 to 2023
$509k
Expressing bacterial bioluminescence in human cell lines: Engineering autobiolumiR43ES022567 · NIEHS · 490 BIOTECH, INC. · PI MORRISON, DAN · 2013 to 2013
$138k
NIEHS NIH HHS R25 ES028976NIEHS NIH HHS R43 ES022567NIEHS NIH HHS R44 ES022567
6 · The paper itself

Abstract

Due to the public health concerns of endocrine-disrupting chemicals, there is an increasing demand to develop improved high-throughput detection assays for enhanced exposure control and risk assessment. A substrate-free, autobioluminescent HEK293

Indexed as

AndrogensBiological AssayTranscriptional ActivationGenes, ReporterHEK293 CellsHumansAndrogensandrogenautobioluminescencebioreporterendocrine disrupting chemical (EDC)HEK293lux

Identifiers

PMID34350768
PMCPMC8371548
OpenAlexW3189431623

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.