Evidence map›Paper›PMID 34350516›Full record

ArticleDigestive diseases and sciences2022

Experimental Intestinal Stenosis Alters Crohn's Disease-Like Intestinal Inflammation in Ileitis-Prone Mice.

Ioannis Georgopoulos, Eleftheria Mavrigiannaki, Sotiria Stasinopoulou, Georgios Renieris, Georgios Nikolakis, Giorgos Bamias, Dina Tiniakos, Ioannis Papaconstantinou

Abstract read
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Article in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Authors' Reply.The American journal of pathology · 2024
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Ioannis GeorgopoulosDepartment of Pediatric Surgery, 'Agia Sofia' Children's Hospital, Thivon and Papadiamantopoulou Street, 11527, Athens, Greece. ioannis.georgopoulos@med.uoa.gr.ORCID 0000-0002-5388-8766
Eleftheria MavrigiannakiDepartment of Pediatric Surgery, 'Agia Sofia' Children's Hospital, Thivon and Papadiamantopoulou Street, 11527, Athens, Greece.
Sotiria StasinopoulouDepartment of Pathology, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Georgios Renieris4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Georgios NikolakisDepartments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Medical School Brandenburg Theodor Fontane, Dessau, Germany.
Giorgos BamiasGastrointestinal Unit, 3rd Department of Internal Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Dina TiniakosDepartment of Pathology, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Ioannis Papaconstantinou2nd Department of Surgery, Aretaieion University Hospital, Medical School, National and Kapodistrian University of Athens, Vasilissis Sofias Ave. 76, 11528, Athens, Greece.
National and Kapodistrian University of Athens · GRIaso Children’s Hospital · GRMedizinische Hochschule Brandenburg Theodor Fontane · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClinical observations indicate that mechanical factors contribute to the expression or recurrence of Crohn's disease. We investigated whether the creation of an intestinal stenosis could alter the severity of the expected Crohn-like ileitis, in a Crohn's disease animal model, the TNF

methodsThirty-six, 6-weeks-old TNF

resultsThe triple suture stenosis induced significant muscular hypertrophy proximal to interventional site which was more prominent in TNF

conclusionThe creation of a stenosis in the terminal ileum of TNF

Indexed as

Crohn DiseaseIleitisIntestinal ObstructionAnimalsConstriction, PathologicHumansInflammationMiceTumor Necrosis Factor-alphaTumor Necrosis Factor-alphaCrohn’s disease animal modelIntestinal stenosisIntraluminal pressureMechanical factors in Crohn’sTNFDare mice

Identifiers

PMID34350516
OpenAlexW3188365033

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.