ArticleArchives of virology2021
A proposed division of the family Picornaviridae into subfamilies based on phylogenetic relationships and functional genomic organization.
Article in Archives of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structure and function of type IV IRES in picornaviruses: a systematic review.Frontiers in microbiology · 2024Pooled it
- First isolation of a novel tottorivirus from wild boar faeces in Japan.The Journal of general virology · 2026Article
- Completion of the 5' end of the porcine teschovirus genome reveals a functional S-segment and enables reverse genetics.Journal of virology · 2026Article
- Emergence of Two Porcine Variants of Human Coxsackievirus B5 and B4 in the 20th Century That Caused Swine Vesicular Disease: A Retrospective Review.Pathogens (Basel, Switzerland) · 2026Review
- Genetic characterization of two novel picornaviruses from birds, white-tailed eagle (Haliaeetus albicilla) and pied avocet (Recurvirostra avosetta) in Hungary.Scientific reports · 2026Article
- Comprehensive hallmark gene sequence, genomic and structural analysis clarifies new and established taxa within theVirus evolution · 2026Article
- Genomic characterization of two duck-origin picornaviruses with seven putative 2A peptides.Frontiers in veterinary science · 2026Article
- The p48 isoform of the PA2G4/EBP1/ITAF45 oncoprotein is required for the encephalomyocarditis virus IRES-driven translation initiation.Nucleic acids research · 2025Article
- Molecular epidemiology of foot and mouth disease virus in Iran during 2019 and 2023.Scientific reports · 2025Article
- Enterovirus C recombination groups: RNA sequence similarity and the viral polymerase underpin sexual replication mechanisms.Journal of virology · 2025Article
- Genomic characterization of a novel sakobuvirus (family Picornaviridae) from a European badger (Meles meles) in Hungary.Archives of virology · 2025Article
- Picornavirus Evolution: Genomes Encoding Multiple 2AViruses · 2024Article
- Identification of a new bovine picornavirus (Journal of veterinary science · 2024Article
- Article
- Identification and Genomic Characterization of BovineViruses · 2024Article
- The Picornaviridae Family: Knowledge Gaps, Animal Models, Countermeasures, and Prototype Pathogens.The Journal of infectious diseases · 2023Article
- Identification of Multiple Novel Viruses in Fecal Samples of Black-Necked Cranes Using Viral Metagenomic Methods.Viruses · 2023Article
- Advances in the Relationship between Respiratory Viruses and Asthma.Journal of clinical medicine · 2023Review
- Virome Analysis Provides an Insight into the Viral Community of Chinese Mitten CrabMicrobiology spectrum · 2023Article
- Prevalence and genetic diversity in bovine parechovirus infecting Japanese cattle.Archives of virology · 2023Article
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3 authors.
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Abstract
The highly diverse virus family Picornaviridae presently comprises 68 approved genera with 158 species plus many unassigned viruses. In order to better match picornavirus taxonomy to the functional and genomic groupings between genera, the establishment of five subfamilies (Caphthovirinae, Kodimesavirinae, Ensavirinae, Paavivirinae and Heptrevirinae) is proposed. The subfamilies are defined by phylogenetic analyses of 3CD (precursor of virus-encoded proteinase and polymerase) and P1 (capsid protein precursor) coding sequences and comprise between 7 and 22 currently approved virus genera. Due to the high within-subfamily and between-subfamily divergences of the picornavirus genera, p-distance estimates are unsuited for the demarcation of subfamilies. Members of the proposed subfamilies typically show some commonalities in their genome organisations, including VP1/2A cleavage mechanisms and possession of leader proteins. Other features, such as internal ribosomal entry site types, are more variable within and between members of genera. Some subfamilies are characterised by homology of proteins 1A, 2A, 2B and 3A encoded by members, which do not belong to the canon of orthologous picornavirus proteins. The proposed addition of a subfamily layer to the taxonomy of picornaviruses provides a valuable additional organisational level to the family that acknowledges the existence of higher-level evolutionary groupings of its component genera.
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