Evidence map›Paper›PMID 34350403›Full record

ArticleRadiology. Artificial intelligence2021

A Deep Learning Approach to Re-create Raw Full-Field Digital Mammograms for Breast Density and Texture Analysis.

Hai Shu, Tingyu Chiang, Peng Wei, Kim-Anh Do, Michele D Lesslie, Ethan O Cohen, Ashmitha Srinivasan, Tanya W Moseley, Lauren Q Chang Sen, Jessica W T Leung and 3 more

Open access · greenAbstract read
In one paragraph

Article in Radiology. Artificial intelligence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Radiomics, deep learning and early diagnosis in oncology.Emerging topics in life sciences · 2021
    Review
  4. BiTr-Unet: a CNN-Transformer Combined Network for MRI Brain Tumor Segmentation.Brainlesion : glioma, multiple sclerosis, stroke and traumatic brain injuries. BrainLes (Workshop) · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Hai ShuDepartments of Biostatistics (H.S., P.W., K.A.D.), Diagnostic Radiology (T.C., M.D.L., E.O.C., A.S., T.W.M., L.Q.C.S., J.W.T.L., O.O.W.), and Clinical Cancer Prevention (J.B.D., S.M.H.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Department of Biostatistics, School of Global Public Health, New York University, New York, NY (H.S.).ORCID https://orcid.org/0000-0002-6968-4063
Tingyu ChiangDepartments of Biostatistics (H.S., P.W., K.A.D.), Diagnostic Radiology (T.C., M.D.L., E.O.C., A.S., T.W.M., L.Q.C.S., J.W.T.L., O.O.W.), and Clinical Cancer Prevention (J.B.D., S.M.H.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Department of Biostatistics, School of Global Public Health, New York University, New York, NY (H.S.).
Peng WeiDepartments of Biostatistics (H.S., P.W., K.A.D.), Diagnostic Radiology (T.C., M.D.L., E.O.C., A.S., T.W.M., L.Q.C.S., J.W.T.L., O.O.W.), and Clinical Cancer Prevention (J.B.D., S.M.H.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Department of Biostatistics, School of Global Public Health, New York University, New York, NY (H.S.).ORCID https://orcid.org/0000-0001-7758-6116
Kim-Anh DoDepartments of Biostatistics (H.S., P.W., K.A.D.), Diagnostic Radiology (T.C., M.D.L., E.O.C., A.S., T.W.M., L.Q.C.S., J.W.T.L., O.O.W.), and Clinical Cancer Prevention (J.B.D., S.M.H.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Department of Biostatistics, School of Global Public Health, New York University, New York, NY (H.S.).ORCID https://orcid.org/0000-0001-8710-7131
Michele D LesslieDepartments of Biostatistics (H.S., P.W., K.A.D.), Diagnostic Radiology (T.C., M.D.L., E.O.C., A.S., T.W.M., L.Q.C.S., J.W.T.L., O.O.W.), and Clinical Cancer Prevention (J.B.D., S.M.H.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Department of Biostatistics, School of Global Public Health, New York University, New York, NY (H.S.).ORCID https://orcid.org/0000-0001-5756-6310
Ethan O CohenDepartments of Biostatistics (H.S., P.W., K.A.D.), Diagnostic Radiology (T.C., M.D.L., E.O.C., A.S., T.W.M., L.Q.C.S., J.W.T.L., O.O.W.), and Clinical Cancer Prevention (J.B.D., S.M.H.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Department of Biostatistics, School of Global Public Health, New York University, New York, NY (H.S.).ORCID https://orcid.org/0000-0002-2770-5057
Ashmitha SrinivasanDepartments of Biostatistics (H.S., P.W., K.A.D.), Diagnostic Radiology (T.C., M.D.L., E.O.C., A.S., T.W.M., L.Q.C.S., J.W.T.L., O.O.W.), and Clinical Cancer Prevention (J.B.D., S.M.H.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Department of Biostatistics, School of Global Public Health, New York University, New York, NY (H.S.).
Tanya W MoseleyDepartments of Biostatistics (H.S., P.W., K.A.D.), Diagnostic Radiology (T.C., M.D.L., E.O.C., A.S., T.W.M., L.Q.C.S., J.W.T.L., O.O.W.), and Clinical Cancer Prevention (J.B.D., S.M.H.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Department of Biostatistics, School of Global Public Health, New York University, New York, NY (H.S.).ORCID https://orcid.org/0000-0002-2018-8253
Lauren Q Chang SenDepartments of Biostatistics (H.S., P.W., K.A.D.), Diagnostic Radiology (T.C., M.D.L., E.O.C., A.S., T.W.M., L.Q.C.S., J.W.T.L., O.O.W.), and Clinical Cancer Prevention (J.B.D., S.M.H.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Department of Biostatistics, School of Global Public Health, New York University, New York, NY (H.S.).ORCID https://orcid.org/0000-0002-1980-7977
Jessica W T LeungDepartments of Biostatistics (H.S., P.W., K.A.D.), Diagnostic Radiology (T.C., M.D.L., E.O.C., A.S., T.W.M., L.Q.C.S., J.W.T.L., O.O.W.), and Clinical Cancer Prevention (J.B.D., S.M.H.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Department of Biostatistics, School of Global Public Health, New York University, New York, NY (H.S.).
Jennifer B DennisonDepartments of Biostatistics (H.S., P.W., K.A.D.), Diagnostic Radiology (T.C., M.D.L., E.O.C., A.S., T.W.M., L.Q.C.S., J.W.T.L., O.O.W.), and Clinical Cancer Prevention (J.B.D., S.M.H.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Department of Biostatistics, School of Global Public Health, New York University, New York, NY (H.S.).
Sam M HanashDepartments of Biostatistics (H.S., P.W., K.A.D.), Diagnostic Radiology (T.C., M.D.L., E.O.C., A.S., T.W.M., L.Q.C.S., J.W.T.L., O.O.W.), and Clinical Cancer Prevention (J.B.D., S.M.H.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Department of Biostatistics, School of Global Public Health, New York University, New York, NY (H.S.).
Olena O WeaverDepartments of Biostatistics (H.S., P.W., K.A.D.), Diagnostic Radiology (T.C., M.D.L., E.O.C., A.S., T.W.M., L.Q.C.S., J.W.T.L., O.O.W.), and Clinical Cancer Prevention (J.B.D., S.M.H.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030; and Department of Biostatistics, School of Global Public Health, New York University, New York, NY (H.S.).ORCID https://orcid.org/0000-0002-0086-8972
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

purposeTo develop a computational approach to re-create rarely stored for-processing (raw) digital mammograms from routinely stored for-presentation (processed) mammograms. MATERIALS AND

methodsIn this retrospective study, pairs of raw and processed mammograms collected in 884 women (mean age, 57 years ± 10 [standard deviation]; 3713 mammograms) from October 5, 2017, to August 1, 2018, were examined. Mammograms were split 3088 for training and 625 for testing. A deep learning approach based on a U-Net convolutional network and kernel regression was developed to estimate the raw images. The estimated raw images were compared with the originals by four image error and similarity metrics, breast density calculations, and 29 widely used texture features.

resultsIn the testing dataset, the estimated raw images had small normalized mean absolute error (0.022 ± 0.015), scaled mean absolute error (0.134 ± 0.078) and mean absolute percentage error (0.115 ± 0.059), and a high structural similarity index (0.986 ± 0.007) for the breast portion compared with the original raw images. The estimated and original raw images had a strong correlation in breast density percentage (Pearson

conclusionThis deep learning approach performed well in re-creating raw mammograms with strong agreement in four image evaluation metrics, breast density, and the majority of 29 widely used texture features.

Indexed as

BreastConvolutional Neural Network (CNN)Deep learning algorithmsMachine Learning AlgorithmsMammographySupervised Learning

Identifiers

PMID34350403
PMCPMC8328112
OpenAlexW3155189856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.