ArticleVirusdisease2021
Molecular characterization of canine parvovirus from domestic dogs in Nigeria: Introduction and spread of a CPV-2c mutant and replacement of older CPV-2a by the "new CPV-2a" strain.
Article in Virusdisease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- Genome Sequences of Canine Parvovirus Type 2c Prevalent in Western Mexico.Archives of Razi Institute · 2024Article
- First genetic detection and characterization of canine parvovirus type 2 (Carnivore protoparvovirus 1) in southwestern Ethiopia.Veterinary research communications · 2023Article
- Detection of Selected Canine Viruses in Nigerian Free-Ranging Dogs Traded for Meat Consumption.Animals : an open access journal from MDPI · 2023Article
- Investigation of Carnivore protoparvovirus 1 and Amdoparvovirus infections in red fox populations of the Italian Dolomites.Veterinary research communications · 2022Article
- Molecular characterization ofFrontiers in veterinary science · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canine parvovirus (CPV) is a contagious and highly pathogenic virus of dogs. After its first report in 1978, the CPV original type (CPV-2) was rapidly and totally replaced by three antigenic variants named CPV-2a, CPV-2b and CPV-2c that circulate in various countries at different frequencies and recently reported in Nigeria. This study describes the molecular characterization of 28 CPV strains in dogs presenting with gastroenteritis in veterinary clinics at Lagos and Ibadan, Nigeria. The results show the predominance (92.8%) of CPV-2a, while CPV-2c was found only in two samples. Phylogenetic analyses revealed that the CPV Nigerian strains were closely related to Asian strains and 26 CPV-2a out of 28 CPV sequences fell into 2 different subclades consistent with predicted amino acid mutations at position 267, 321, 324 and 440. Lys321Asn was evident in all the Nigerian strains whilst Phe267Tyr and Tyr324Ile were observed in 96.4% of the sequences, respectively. Thr440Ala occurred in 89.3% of sequences from this study. The new CPV-2a was predominant and appears to have replaced other CPV-2a strains in South-western Nigeria whilst the CPV-2c strain which is identical to the isolate recently reported in Northern Nigeria, may have been introduced in this country at the time of this study. Monitoring virus epidemiology is important to better understand the dynamics of CPV evolution and the eventual need to change or improve existing vaccination strategies.
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