Evidence map›Paper›PMID 34350313›Full record

ArticleOptica2019

Reliable deep-learning-based phase imaging with uncertainty quantification.

Yujia Xue, Shiyi Cheng, Yunzhe Li, Lei Tian

Abstract read
In one paragraph

Article in Optica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Task-Driven Uncertainty Quantification in Inverse Problems via Conformal Prediction.Computer vision - ECCV ... : ... European Conference on Computer Vision : proceedings. European Conference on Computer Vision · 2025
    Article
  11. Article
  12. Review
  13. Review
  14. On the use of deep learning for phase recovery.Light, science & applications · 2024
    Review
  15. Article
  16. Article
  17. Roadmap on Label-Free Super-Resolution Imaging.Laser & photonics reviews · 2023
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yujia XueDepartment of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 02215, USA.
Shiyi ChengDepartment of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 02215, USA.
Yunzhe LiDepartment of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 02215, USA.
Lei TianDepartment of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 02215, USA.ORCID 0000-0002-1316-4456

Funding

Development of label-free computational flow cytometry for high-throughput micro-organism classificationR21GM128020 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MERTZ, JEROME · 2018 to 2019
$446k
NIGMS NIH HHS R21 GM128020
6 · The paper itself

Abstract

Emerging deep-learning (DL)-based techniques have significant potential to revolutionize biomedical imaging. However, one outstanding challenge is the lack of reliability assessment in the DL predictions, whose errors are commonly revealed only in hindsight. Here, we propose a new Bayesian convolutional neural network (BNN)-based framework that overcomes this issue by quantifying the uncertainty of DL predictions. Foremost, we show that BNN-predicted uncertainty maps provide surrogate estimates of the true error from the network model and measurement itself. The uncertainty maps characterize imperfections often unknown in real-world applications, such as noise, model error, incomplete training data, and out-of-distribution testing data. Quantifying this uncertainty provides a per-pixel estimate of the confidence level of the DL prediction as well as the quality of the model and data set. We demonstrate this framework in the application of large space-bandwidth product phase imaging using a physics-guided coded illumination scheme. From only five multiplexed illumination measurements, our BNN predicts gigapixel phase images in both static and dynamic biological samples with quantitative credibility assessment. Furthermore, we show that low-certainty regions can identify spatially and temporally rare biological phenomena. We believe our uncertainty learning framework is widely applicable to many DL-based biomedical imaging techniques for assessing the reliability of DL predictions.

Identifiers

PMID34350313
PMCPMC8329751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.