ReviewAnnals of translational medicine2021
The role of vitamin D and vitamin D deficiency in orthopaedics and traumatology-a narrative overview of the literature.
Review in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Vitamin D Metabolic Pathway Components in Orthopedic Patientes-Systematic Review.International journal of molecular sciences · 2022Pooled it
- Article
- Vitamin D deficiency and disease conditions relevant to: Orthopaedic translation.Journal of orthopaedic translation · 2026Review
- Parathyroid Hormone in the Management of Pelvic Fragility Fractures: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Vitamin D and Fracture Healing.Advances in experimental medicine and biology · 2026Review
- Lower preoperative vitamin D levels are associated with poor clinical outcomes in elderly patients with osteoporotic vertebral compression fractures after percutaneous vertebroplasty.Frontiers in medicine · 2026Article
- Exploring the predictors of postoperative complications in hand surgery: a cross-sectional analysis.BMC surgery · 2025Article
- Review
- The Role of Vitamin D in Postoperative Tendon Healing: A Scoping Review.Orthopaedic journal of sports medicine · 2025Review
- Correlation between Vitamin D Levels and Healing Time in Lower Limb Fractures.Journal of orthopaedic case reports · 2025Article
- High Prevalence of Vitamin D Deficiency in Patients Undergoing Total Shoulder or Elbow Arthroplasty.Nutrients · 2025Article
- Vitamin D Supplementation Improves Muscle Mass, Physical Function, and Quality of Life in Patients With Degenerative Lumbar Disease.Clinical and translational science · 2025Article
- Vitamin D levels and bone mineral density: a prospective cross-sectional analysis of young orthopedic trauma patients at a rural United States trauma center.Journal of trauma and injury · 2024Article
- Prevalence and Associated Risk Factors for Hypovitaminosis D in Patients Scheduled for Primary Total Knee Arthroplasty in Germany.Nutrients · 2024Observational
- Article
- Article
- Vitamin D and pediatric bone health: Important information and considerations for the pediatric orthopaedic surgeon.Journal of the Pediatric Orthopaedic Society of North America · 2024Article
- Vitamin D Deficiency Is Frequent in Patients with Rapidly Destructive Osteoarthritis-Data from a Single-Center Analysis.Journal of clinical medicine · 2024Article
- Editorial: The bone/bone marrow microenvironment: A hub for immune regulation of the tumor cells fate.Frontiers in immunology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D is considered to play an important role in musculoskeletal health. It's classical function is the regulation of calcium and phosphate homeostasis, thus ensuring a balanced bone metabolism that is characterised by an equal amount of bone resorption and bone formation. In the past decades, a plethora of pre-clinical and clinical studies reporting on potential health-beneficial properties of vitamin D have emerged. Moreover, there is an abundance of reports highlighting vitamin D deficiency and insufficiency in patients with almost innumerable diseases. Further, it is estimated that more than one billion people globally are affected by insufficient vitamin D levels. As such, research on vitamin D has been particularly popular over the past years. In orthopaedics and traumatology, most studies describe favourable effects of vitamin D in general. However, the relative importance of vitamin D is oftentimes debated. In this narrative review of the literature, we consider first, the properties of vitamin D and how vitamin D, vitamin D deficiency and the vitamin D receptor (VDR) impact on musculoskeletal health. Secondly, we provide an overview of studies reporting the prevalence of vitamin D deficiency in traumatology and diverse orthopaedic diseases including bone oncology. Lastly, we emphasise recent findings and touch on future perspectives in vitamin D research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.