Evidence map›Paper›PMID 34350170›Full record

ArticleFrontiers in cell and developmental biology2021

Leukemia Inhibitory Factor Induces Proopiomelanocortin via CRH/CRHR Pathway in Mouse Trophoblast.

He Wang, Hiromi Sakata-Haga, Hiroko Masuta, Mitsuhiro Tomosugi, Tsuyoshi Tsukada, Hiroki Shimada, Daisuke Sakai, Hiroki Shoji, Toshihisa Hatta

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

He WangDepartment of Anatomy, Kanazawa Medical University, Uchinada, Japan.
Hiromi Sakata-HagaDepartment of Anatomy, Kanazawa Medical University, Uchinada, Japan.
Hiroko MasutaDepartment of Anatomy, Kanazawa Medical University, Uchinada, Japan.
Mitsuhiro TomosugiDepartment of Anatomy, Kanazawa Medical University, Uchinada, Japan.
Tsuyoshi TsukadaDepartment of Anatomy, Kanazawa Medical University, Uchinada, Japan.
Hiroki ShimadaDepartment of Medical Science, Kanazawa Medical University, Uchinada, Japan.
Daisuke SakaiDepartment of Biology, Kanazawa Medical University, Uchinada, Japan.
Hiroki ShojiDepartment of Biology, Kanazawa Medical University, Uchinada, Japan.
Toshihisa HattaDepartment of Anatomy, Kanazawa Medical University, Uchinada, Japan.
Kanazawa Medical University · JPFirst Hospital of China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously showed that maternal leukemia inhibitory factor (LIF) induces placental production of adrenocorticotropic hormone (ACTH), which stimulates fetal nucleated red blood cells to further secrete LIF and promote neurogenesis in rodent brains. However, the underlying mechanism of LIF-dependent ACTH induction remains unclear. Recently, we found that LIF induces corticotropin-releasing hormone (CRH) in mouse trophoblast stem cells. This finding supports the results of a previous study that CRH, which is produced by the placenta, induces placental ACTH production. In this study, we examined whether the effects of LIF are mediated by the induction of

Indexed as

corticotropin-releasing hormonecorticotropin-releasing hormone receptorleukemia inhibitory factormouse placentamouse trophoblast stem cellsproopiomelanocortin

Identifiers

PMID34350170
PMCPMC8326836
OpenAlexW3184549237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.