Evidence map›Paper›PMID 34350160›Full record

ArticleFrontiers in bioengineering and biotechnology2021

Bilayer Membrane Composed of Mineralized Collagen and Chitosan Cast Film Coated With Berberine-Loaded PCL/PVP Electrospun Nanofiber Promotes Bone Regeneration.

Yuhan Zhang, Ting Wang, Juan Li, Xiaoming Cui, Mingxia Jiang, Mogen Zhang, Xiaoli Wang, Weifen Zhang, Zhijun Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
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  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Traditional Chinese Medicine Compound-Loaded Materials in Bone Regeneration.Frontiers in bioengineering and biotechnology · 2022
    Review
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  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yuhan ZhangClinical College, Weifang Medical University, Weifang, China.
Ting WangShandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang Medical University, Weifang, China.
Juan LiShandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang Medical University, Weifang, China.
Xiaoming CuiShandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang Medical University, Weifang, China.
Mingxia JiangShandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang Medical University, Weifang, China.
Mogen ZhangClinical College, Weifang Medical University, Weifang, China.
Xiaoli WangCollege of Medical Imaging, Weifang Medical University, Weifang, China.
Weifen ZhangShandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang Medical University, Weifang, China.
Zhijun LiuDepartment of Microbiology, Weifang Medical University, Weifang, China.
Weifang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone defects are difficult to repair and reconstruct as bone regeneration remains technically challenging, with exogenous factors required to accelerate this process. Biodegradable synthetic scaffolds are promising materials for stimulating bone tissue repair. In this study, we investigated whether a bilayer membrane that includes mineralized collagen (MC) and chitosan (CS) delivering berberine (BER)-a typical Chinese herbal monomer-could promote bone healing in a rat model. An MC/CS cast film was coated with polycaprolactone (PCL)/polyvinylpyrrolidone (PVP) electrospun nanofibers loaded with BER, yielding the BER@PCL/PVP-MC/CS bilayer membrane. The 3-dimensional structure had nanofibers of uniform diameter and showed good hydrophilicity; the bilayer membrane showed favorable mechanical properties. BER@PCL/PVP-MC/CS enhanced the proliferation and attachment of MC3T3-E1 cells

Indexed as

berberinebone regenerationcast filmchitosanelectrospinningmineralized collagennanofiber

Identifiers

PMID34350160
PMCPMC8327095
OpenAlexW3185255876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.