Evidence map›Paper›PMID 34350060›Full record

ArticleOncoimmunology2021

Genomic complexity is associated with epigenetic regulator mutations and poor prognosis in diffuse large B-cell lymphoma.

Hua You, Zijun Y Xu-Monette, Li Wei, Harry Nunns, Máté L Nagy, Govind Bhagat, Xiaosheng Fang, Feng Zhu, Carlo Visco, Alexandar Tzankov and 19 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 10 countries.

Hua YouDepartment of Hematology and Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China.
Zijun Y Xu-MonetteDepartment of Hematology and Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China.ORCID 0000-0002-7615-3949
Li WeiHematopathology Division and Department of Pathology, Duke University Medical Center, Durham, North Carollina, USA.
Harry NunnsDuke Cancer Institute, Durham, North Caronlina, USA.
Máté L NagyDuke Cancer Institute, Durham, North Caronlina, USA.
Govind BhagatNeoGenomics Laboratories, Aliso Viejo, California, USA.
Xiaosheng FangHematopathology Division and Department of Pathology, Duke University Medical Center, Durham, North Carollina, USA.ORCID 0000-0002-4515-9731
Feng ZhuHematopathology Division and Department of Pathology, Duke University Medical Center, Durham, North Carollina, USA.
Carlo ViscoDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.
Alexandar TzankovDepartment of Medicine, Section of Hematology, University of Verona, Verona, Italy.
Karen DybkaerDepartment of Pathology, Institute of Pathology,University Hospital Basel, Switzerland.
April ChiuClinical Department, Aalborg University Hospital, Aalborg, Denmark.
Wayne TamHematopathology Department, Mayo Clinic, Rochester, Minnesota, USA.
Youli ZuDepartment of Pathology, Weill Medical College of Cornell University, New York, New York, USA.
Eric D HsiDepartment of Pathology and Genomic Medicine, The Methodist Hospital, Houston, Texas, USA.
Fredrick B HagemeisterDepartment of Pathology, Cleveland Clinic, Cleveland, Ohio, USA.
Jooryung HuhDepartment of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Maurilio PonzoniDepartment of Pathology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea.
Andrés J M FerreriDepartment of Pathology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea.
Michael B MøllerLymphoma Unit, Department of Onco-Hematology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Benjamin M ParsonsDepartment of Pathology, Odense University Hospital, Odense, Denmark.ORCID 0000-0002-5634-2937
J Han Van KriekenHematology & Oncology, Gundersen Lutheran Health System, La Crosse, Wisconsin, USA.
Miguel A PirisDepartment of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands.
Jane N WinterPathology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
Yong LiDepartment of Medicine (Hematology and Oncology), Feinberg School of Medicine, Northwestern University, Chicago, Illinois,USA.
Qingyan AuDuke Cancer Institute, Durham, North Caronlina, USA.
Bing XuDepartment of Medicine, Baylor College of Medicine, Houston, Texas,USA.
Maher AlbitarDepartment of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian,China.
Ken H YoungDepartment of Hematology and Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China.ORCID 0000-0002-5755-8932
Duke Medical Center · USNeoGenomics (United States) · USVita-Salute San Raffaele University · ITAalborg University Hospital · DKAsan Medical Center · KRBaylor College of Medicine · USCancer Institute (WIA) · INCenter for Genomic Science · ITCleveland Clinic · USCornell University · USFirst Affiliated Hospital of Xiamen University · CNGundersen Health System · USHouston Methodist · USMarqués de Valdecilla University Hospital · ESMayo Clinic · USNewYork–Presbyterian Hospital · USNorthwestern University · USOdense University Hospital · DKRadboud University Nijmegen · NLThe University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma with high mutation burdens but a low response rate to immune checkpoint inhibitors. In this study, we performed targeted next-generation sequencing and fluorescent multiplex immunohistochemistry, and investigated the clinical significance and immunological effect of mutation numbers in 424 DLBCL patients treated with standard immunochemotherapy. We found that

Indexed as

Lymphoma, Large B-Cell, DiffuseEpigenesis, GeneticGenomicsHumansMutationPrognosisDLBCLepigeneticgenomic instabilityINDELKMT2DPD-1PD-L1TP53tumor microenvironmentTumor mutation burden

Identifiers

PMID34350060
PMCPMC8293967
OpenAlexW3186347224

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.