ArticleUpsala journal of medical sciences2021
Association between open-angle glaucoma and Alzheimer's disease in Sweden: a long-term population-based follow-up study.
Article in Upsala journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Risk of glaucoma to subsequent dementia or cognitive impairment: a systematic review and meta-analysis.Aging clinical and experimental research · 2024Pooled it
- Relative Risks for Dementia among Individuals with Glaucoma: A Meta-Analysis of Observational Cohort Studies.Korean journal of ophthalmology : KJO · 2023Pooled it
- Primary open-angle glaucoma as a marker of upcoming Alzheimer's disease: A 20-year Danish National Registry-Based Study.Acta ophthalmologica · 2026Article
- Construction and verification of prediction model for Alzheimer's disease in diabetic patients.Frontiers in endocrinology · 2025Article
- Exploring Cognitive Impairments Associated with Primary Open-Angle Glaucoma and Exfoliation Glaucoma.Biomedicines · 2024Article
- Risk of Alzheimer's Disease and Related Dementias in Persons with Glaucoma: A National Cohort Study.Ophthalmology · 2024Article
- Glaucoma and cognitive function trajectories in a population-based study: Findings from the health and retirement study.Journal of the American Geriatrics Society · 2022Article
- Circular RNA circ_0005835 promotes promoted neural stem cells proliferation and differentiate to neuron and inhibits inflammatory cytokines levels through miR-576-3p in Alzheimer's disease.Environmental science and pollution research international · 2022Article
- Glaucoma and Systemic Neurodegenerative Diseases: The Brain-Eye Continuum.Journal of current glaucoma practiceReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOpen-angle glaucoma (OAG) and Alzheimer's disease (AD) are two age-related neurodegenerative diseases of significant public health importance. Epidemiological studies have indicated that there might be an association between the disorders.
methodsPredictors of AD, including mixed and unspecified dementia, were analysed in a cohort of 712 residents aged 65-74 years, examined in a population survey in the rural district of Tierp, Sweden, from 1984 to 1986. To expand the sample size, 821 people were recruited by means of glaucoma case records established at the Eye Department in Tierp from 1978 to 2007. In this way, the cohort comprised 1,533 people, representing more than 21,000 person-years at risk. Medical records were reviewed to identify subjects diagnosed with dementia. Those with a follow-up duration shorter than 2 years were excluded.
resultsBy the conclusion of the study, in August 2020, 307 subjects had received a diagnosis of AD, including mixed and unspecified dementia. Of these cases, 55 were affected with definite OAG at baseline. Higher age and ischemic heart disease were the only predictors of AD identified. In multivariate analysis, adjusting for age, participation in the population survey and competing events, no association was found between OAG and AD (hazard ratio 1.08; 95% confidence interval: 0.80-1.47).
conclusionIn this long-term follow-up study of subjects aged 65-74 years old in Sweden, OAG was not associated with AD.
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