ArticleOxidative medicine and cellular longevity2021
The Secretome Deregulations in a Rat Model of Endotoxemic Shock.
Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Characterization of complement C3 as a marker of alpha-amanitin toxicity by comparative secretome profiling.Toxicological research · 2023Article
- Review
- Endotoxin tolerance and low activation of TLR-4/NF-κB axis in monocytes of COVID-19 patients.Journal of molecular medicine (Berlin, Germany) · 2023Article
- Identification of biomarkers and the mechanisms of multiple trauma complicated with sepsis using metabolomics.Frontiers in public health · 2022Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSeptic shock is a systemic inflammatory response syndrome associated with organ failures. Earlier clinical diagnosis would be of benefit to a decrease in the mortality rate. However, there is currently a lack of predictive biomarkers. The secretome is the set of proteins secreted by a cell, tissue, or organism at a given time and under certain conditions. The plasma secretome is easily accessible from biological fluids and represents a good opportunity to discover new biomarkers that can be studied with nontargeted "omic" strategies.
aimsTo identify relevant deregulated proteins (DEP) in the secretome of a rat endotoxemic shock model.
methodsEndotoxemic shock was induced in rats by intravenous injection of lipopolysaccharides (LPS,
resultsNinety minutes after shock induction, the LPS group presents a reduction in MAP (-45%,
conclusionThis study proposes an approach to identify relevant DEP in septic shock and brings new insights into the understanding of the secretome adaptations upon sepsis.
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