Evidence map›Paper›PMID 34349868›Full record

ArticleCardiology research2021

Corrected QT Interval Prolongation, Elevated Troponin, and Mortality in Hospitalized COVID-19 Patients.

Rana Al-Zakhari, Muhammed Atere, William Lim, Mustafa Abdulrahman, Shahnaz Akhtar, Nicholas Sheets, Thomas Joyce, Veronika Stefanishina, Edmund Appiah-Kubi, Philipa Owusu-Antwi and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Cardiology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Observational
  3. Review
  4. Observational
  5. Article
  6. Review
  7. The QT Interval in Research.Cardiology research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Rana Al-ZakhariDepartment of Medicine, Richmond University Medical Center, Staten Island, NY, USA.ORCID https://orcid.org/0000-0002-9919-5690
Muhammed AtereDepartment of Medicine, Richmond University Medical Center, Staten Island, NY, USA.
William LimDepartment of Medicine, Richmond University Medical Center, Staten Island, NY, USA.
Mustafa AbdulrahmanDepartment of Medicine, Zucker School of Medicine at Mather/Northwell Health Mather Hospital, Port Jefferson, NY, USA.
Shahnaz AkhtarDepartment of Clinical Research, Richmond University Medical Center, Staten Island, NY, USA.
Nicholas SheetsSt. George's University School of Medicine, Grenada, West Indies.
Thomas JoyceSt. George's University School of Medicine, Grenada, West Indies.
Veronika StefanishinaSt. George's University School of Medicine, Grenada, West Indies.
Edmund Appiah-KubiSt. George's University, Building 300, 3500 Sunrise Highway, Great River, NY 11739, USA.
Philipa Owusu-AntwiSt. George's University, Building 300, 3500 Sunrise Highway, Great River, NY 11739, USA.
Jay NfonoyimDepartment of Medicine, Richmond University Medical Center, Staten Island, NY, USA.
Richard GrodmanDepartment of Medicine-Cardiology, Richmond University Medical Center, Staten Island, NY, USA.
Francesco RotatoriDepartment of Medicine-Cardiology, Richmond University Medical Center, Staten Island, NY, USA.
Richmond University Medical Center · USSt. George's University · GDSt. George's School · USNorthwell Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has risen to the level of a global pandemic. Growing evidence has proven the cardiac involvement in SARS-CoV-2 infection. This study aims to evaluate the ability of cardiovascular complications determined by elevated troponin and electrocardiogram findings (e.g., corrected QT interval (QTc)) in predicting the severity of SARS-CoV-2 infection among hospitalized patients.

methodsThis is a retrospective review of medical records of 800 patients, admitted to Richmond University Medical Center in Staten Island, NY, and tested positive for SARS-CoV-2 between March 1, 2020 and July 31, 2020. A total of 339 patients met the study inclusion and exclusion criteria and were included in statistical analysis.

resultsElevated serum troponin levels on admission statistically correlated with mortality in SARS-CoV-2 patients. Prolonged QTc was shown to have an independent statistically significant association with mortality among patients hospitalized with SARS-CoV-2.

conclusionsGrowing concern for cardiovascular sequelae of coronavirus disease 2019 (COVID-19) has prompted many researchers to investigate the role of cardiovascular complications in mortality due to SARS-CoV-2. Obtaining a simple electrocardiogram for hospitalized patients with COVID-19 could provide an independent prognostic tool and prompt more coordinated treatment strategies to prevent mortality among patients hospitalized with COVID-19.

Indexed as

CardiovascularCoronavirusElectrocardiogramMortalityQTcQTc prolongationSARS-CoV-2Troponin

Identifiers

PMID34349868
PMCPMC8297043
OpenAlexW3182900097

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.