Evidence map›Paper›PMID 34349748›Full record

ArticleFrontiers in microbiology2021

Associative Conditioning Is a Robust Systemic Behavior in Unicellular Organisms: An Interspecies Comparison.

Jose Carrasco-Pujante, Carlos Bringas, Iker Malaina, Maria Fedetz, Luis Martínez, Gorka Pérez-Yarza, María Dolores Boyano, Mariia Berdieva, Andrew Goodkov, José I López and 2 more

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Trainable computation in molecular networks.bioRxiv : the preprint server for biology · 2025
    Article
  4. The "plant neurobiology" revolution.Plant signaling & behavior · 2024
    Review
  5. A heritable iron memory enables decision-making inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Review
  7. Review
  8. Review
  9. Learning in Cnidaria: a summary.Communicative & integrative biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jose Carrasco-PujanteDepartment of Physiology and Cell Biology, Faculty of Health Sciences, The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beersheba, Israel.
Carlos BringasDepartment of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain.
Iker MalainaDepartment of Mathematics, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain.
Maria FedetzDepartment of Cell Biology and Immunology, CSIC, Institute of Parasitology and Biomedicine "López-Neyra", Granada, Spain.
Luis MartínezDepartment of Mathematics, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain.
Gorka Pérez-YarzaDepartment of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain.
María Dolores BoyanoDepartment of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain.
Mariia BerdievaLaboratory of Cytology of Unicellular Organisms, Institute of Cytology Russian Academy of Science, Saint Petersburg, Russia.
Andrew GoodkovLaboratory of Cytology of Unicellular Organisms, Institute of Cytology Russian Academy of Science, Saint Petersburg, Russia.
José I LópezDepartment of Pathology, Cruces University Hospital, Biocruces-Bizkaia Health Research Institute, Barakaldo, Spain.
Shira KnafoDepartment of Physiology and Cell Biology, Faculty of Health Sciences, The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beersheba, Israel.
Ildefonso M De la FuenteDepartment of Mathematics, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The capacity to learn new efficient systemic behavior is a fundamental issue of contemporary biology. We have recently observed, in a preliminary analysis, the emergence of conditioned behavior in some individual amoebae cells. In these experiments, cells were able to acquire new migratory patterns and remember them for long periods of their cellular cycle, forgetting them later on. Here, following a similar conceptual framework of Pavlov's experiments, we have exhaustively studied the migration trajectories of more than 2000 individual cells belonging to three different species:

Indexed as

associative conditioningcellular migrationchemotaxisgalvanotaxislearningPavlov’s experimentssystemic behavior

Identifiers

PMID34349748
PMCPMC8327096

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.