Evidence map›Paper›PMID 34349659›Full record

ArticleFrontiers in pharmacology2021

The Role of HSP90α in Methamphetamine/Hyperthermia-Induced Necroptosis in Rat Striatal Neurons.

Lv-Shuang Liao, Shuang Lu, Wei-Tao Yan, Shu-Chao Wang, Li-Min Guo, Yan-di Yang, Kai Huang, Xi-Min Hu, Qi Zhang, Jie Yan and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

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  12. The regulatory role of Pin1 in neuronal death.Neural regeneration research · 2023
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  18. Review
  19. A bibliometric analysis of PIN1 and cell death.Frontiers in cell and developmental biology · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Lv-Shuang LiaoDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China.
Shuang LuDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China.
Wei-Tao YanDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China.
Shu-Chao WangCenter for Medical Research, The Second Xiangya Hospital of Central South University, Changsha, China.
Li-Min GuoDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China.
Yan-di YangDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China.
Kai HuangDepartment of Human Anatomy and Histoembryolog, School of Basic Medical Sciences, Shaoyang University, Shaoyang, China.
Xi-Min HuDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China.
Qi ZhangDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China.
Jie YanDepartment of Forensic Science, School of Basic Medical Science, Central South University, Changsha, China.
Kun XiongDepartment of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China.
Central South University · CNHunan Institute of Science and Technology · CNSecond Xiangya Hospital of Central South University · CNShaoyang University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methamphetamine (METH) is one of the most widely abused synthetic drugs in the world. The users generally present hyperthermia (HT) and psychiatric symptoms. However, the mechanisms involved in METH/HT-induced neurotoxicity remain elusive. Here, we investigated the role of heat shock protein 90 alpha (HSP90α) in METH/HT (39.5°C)-induced necroptosis in rat striatal neurons and an

Indexed as

heat shock protein 90 alphahyperthermiamethamphetaminenecroptosisreceptor-interacting protein 3

Identifiers

PMID34349659
PMCPMC8326403
OpenAlexW3186412148

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.