Evidence map›Paper›PMID 34349645›Full record

ArticleFrontiers in pharmacology2021

P-Rex1 Cooperates With TGFβR2 to Drive Lung Fibroblast Migration in Pulmonary Fibrosis.

Qing Liang, Yanhua Chang, Jing Liu, Yan Yu, Wancheng Qiu, Jiajia Li, Xu Yang, Guangchun Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Decoding Rho GTPase signalling networks in directed cell migration.Frontiers in cell and developmental biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qing LiangDepartment of Pharmacy, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Yanhua ChangDepartment of Pathology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Jing LiuDepartment of Pharmacy, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Yan YuDepartment of Pharmacy, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Wancheng QiuDepartment of Pharmacy, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Jiajia LiDepartment of Pharmacy, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Xu YangDepartment of Pharmacy, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Guangchun SunDepartment of Pharmacy, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary fibrosis is a kind of interstitial lung disease with progressive pulmonary scar formation, leading to irreversible loss of lung functions. The TGF-β1/Smad signaling pathway plays a key role in fibrogenic processes. It is associated with the increased synthesis of extracellular matrix, enhanced proliferation of fibroblasts, and transformation of alveolar epithelial cells into interstitial cells. We investigated P-Rex1, a PIP

Indexed as

fibroblastmigrationP-Rex1pulmonary fibrosistransforming growth factor β1

Identifiers

PMID34349645
PMCPMC8326510

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.