ArticleJournal of pain research2021
Moderate to Severe Osteoarthritis Pain and Its Impact on Patients in the United States: A National Survey.
Article in Journal of pain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Sleep disturbances and sleep quality among individuals diagnosed with osteoarthritis: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Economic and Humanistic Burden of Osteoarthritis: An Updated Systematic Review of Large Sample Studies.PharmacoEconomics · 2023Pooled it
- Efficacy and safety of fasinumab in an NSAID-controlled study in patients with pain due to osteoarthritis of the knee or hip.BMC musculoskeletal disorders · 2025Trial
- Evaluation of the Effect of New Multimodal Analgesia Regimen for Cardiac Surgery: A Prospective, Randomized Controlled, Single-Center Clinical Study.Drug design, development and therapy · 2023Trial
- Changes in sleep and clinical outcomes in hip osteoarthritis: A longitudinal secondary analysis of a randomised controlled trial.Osteoarthritis and cartilage open · 2026Article
- Identification of alkaline phosphatase as a putative biomarker of anti-NGF treatment-associated arthropathies: Machine learning-assisted analyses of clinical trial data.Osteoarthritis and cartilage open · 2026Article
- Incidences and predictors of moderate-to-severe movement-evoked pain until postoperative day three following gastrointestinal and hepatobiliary surgery: a retrospective study.Journal of anesthesia · 2025Article
- Psychometric evaluation of the Adelphi Adherence Questionnaire (ADAQ©) in adults with osteoarthritis.Journal of patient-reported outcomes · 2024Article
- Prevalence and Predictors of Depression in Women with Osteoarthritis: Cross-Sectional Analysis of Nationally Representative Survey Data.Healthcare (Basel, Switzerland) · 2024Article
- Observational
- Use of electronic health data to identify patients with moderate-to-severe osteoarthritis of the hip and/or knee and inadequate response to pain medications.BMC medical research methodology · 2023Review
- Opioids for Osteoarthritis: Cross-Sectional Survey of Patient Perspectives and Satisfaction.Journal of clinical medicine · 2023Article
- Physician and patient perceptions of surgical procedures for osteoarthritis of the knee in the United States, Europe, and Japan: results of a real-world study.BMC musculoskeletal disorders · 2022Article
- Impact of worst pain severity and morning fatigue profiles on oncology outpatients' symptom burden and quality of life.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Enhancing Collaboration and Integrated Vision on Health: Key Strategies for Addressing Knee Osteoarthritis.International journal of integrated careArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOsteoarthritis (OA) is one of the most common causes of chronic pain and a leading cause of disability in the US. The objective of this study was to examine the clinical and economic burden of OA by pain severity. PATIENTS AND
methodsWe used nationally representative survey data. Adults ≥18 years with self-reported physician-diagnosed OA and experiencing OA pain were included in the study. OA pain severity was measured using the Short Form McGill Pain Questionnaire Visual Analog Scale (SF-MPQ-VAS). Data were collected for demographics, clinical characteristics, health-related quality of life (HRQoL), productivity, OA treatment, adherence to pain medication, and healthcare resource utilization. Univariate analysis was performed to examine differences between respondents with moderate-to-severe OA pain vs those with mild OA pain.
resultsHigher proportions of respondents with moderate-to-severe OA pain (n=3798) compared with mild OA pain (n=2038) were female (69.4% vs 57.3%), <65 years of age (54.8% vs 43.4%), and not employed (70.6% vs 64.5%). Respondents with moderate-to-severe OA pain experienced OA pain daily (80.8% vs 48.8%), were obese (53.0% vs 40.5%), had more comorbidities (sleep disturbance, insomnia, depression, and anxiety), and reported significantly poorer health status and HRQoL, and greater productivity and activity impairment (all
conclusionPatient and clinical burden was significantly greater in moderate-to-severe OA pain respondents vs mild OA pain respondents and may inform decision-making for appropriate resource allocation and effective management strategies that target specific subgroups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.