Evidence map›Paper›PMID 34349398›Full record

ReviewJournal of orthopaedics

A meta-analysis for association of TNF-α -308G>A polymorphism with susceptibility to Ankylosing Spondylitis.

Masoud Mahdinejad-Yazdi, Mohammad Reza Sobhan, Seyed Alireza Dastgheib, Reza Bahrami, Seyed Hossein Shaker, Hamid Mirjalili, Jalal Sadeghizadeh-Yazdi, Masoud Zare-Shehneh, Hossein Neamatzadeh

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of orthopaedics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Masoud Mahdinejad-YazdiDepartment of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad Reza SobhanDepartment of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Seyed Alireza DastgheibDepartment of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Reza BahramiNeonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyed Hossein ShakerDepartment of Emergency Medicine, Iran University of Medical Sciences, Tehran, Iran.
Hamid MirjaliliDepartment of Emergency Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Jalal Sadeghizadeh-YazdiDepartment of Food Science and Technology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Masoud Zare-ShehnehDepartment of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Hossein NeamatzadehDepartment of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Shahid Sadoughi University of Medical Sciences and Health Services · IRShiraz University of Medical Sciences · IRIran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe performed a meta-analysis of all eligible studies on the association of TNF-α -308G>A polymorphism with risk of Ankylosing spondylitis (AS).

methodsA comprehensive literature research was performed in online databases.

resultsA total of 28 studies with 4489 cases and 5919 controls were included. Pooled ORs showed a significant association between TNF-α -308G>A polymorphism and risk of AS. Moreover, stratified analysis by ethnicity showed a significant association between TNF-α -308G>A polymorphism and AS risk in Asians, Caucasians and Mixed populations, but not in Chinese population.

conclusionThis meta-analysis suggested that the TNF-α -308G>A polymorphism was associated with AS risk.

Indexed as

Ankylosing spondylitisEthnicityJoints inflammationMeta-analysisPolymorphismTNF-α

Identifiers

PMID34349398
PMCPMC8319454
OpenAlexW3184718523

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.