Evidence map›Paper›PMID 34349265›Full record

ArticleNature2021

Genetic insights into biological mechanisms governing human ovarian ageing.

Katherine S Ruth, Felix R Day, Jazib Hussain, Ana Martínez-Marchal, Catherine E Aiken, Ajuna Azad, Deborah J Thompson, Lucie Knoblochova, Hironori Abe, Jane L Tarry-Adkins and 266 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07404969 (An Interventional Study Evaluating Telomere and Biological Aging Hallmarks Profiling to Guide an Integrative Traditional Chinese and Conventional Medicine Approach in Women With Post-Treatment Unexplained Infertility), which is not on this map. Cited by 249 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
249citing papers in PubMed, 8 pooled it
66.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07404969 narecruitingnot on this mapstarted 2025, after this paper: background citation

An Interventional Study Evaluating Telomere and Biological Aging Hallmarks Profiling to Guide an Integrative Traditional Chinese and Conventional Medicine Approach in Women With Post-Treatment Unexplained Infertility

TypeinterventionalSponsorBEYOND GENOMiX SA, AG, LtdRan2025 to 2026Enrolled15ConditionsIdiopathic Infertility, Infertility Unexplained, Infertility (IVF Patients), Infertility Assisted Reproductive TechnologyArms1. Aging Hallmarks Biomarker Profiling (Telomere-Based), 2. Integrative Botanical and Nutraceutical Intervention, 3. Natural Conception or Assisted Reproductive Technologies
3 · Its place in the literature

Who cites it

249 citing papers in PubMed, 8 syntheses or guidelines pooled it, 423 citations in OpenAlex.

  1. Pooled it
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  9. Article
  10. Hormone therapy (HT) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint FIGO and IMS position paper.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Article
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  14. A Novel Role of DELTEX2 in Maintaining Genomic Stability of Granulosa Cells During Ovarian Aging.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  15. Ovarian ageing: from biological constraint to emerging therapeutic frontier.Journal of assisted reproduction and genetics · 2026
    Review
  16. Review
  17. Article
  18. geneXplore: An Interactive Browser for X Chromosome-Wide Association Study Results.medRxiv : the preprint server for health sciences · 2026
    Article
  19. Article
  20. Article

189 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

276 authors at 20 institutions in 21 countries.

Katherine S Ruth *Genetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Felix R Day *MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Jazib Hussain *DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ana Martínez-Marchal *Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Catherine E AikenUniversity of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Ajuna AzadDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Deborah J ThompsonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Lucie KnoblochovaInstitute of Animal Physiology and Genetics of the Czech Academy of Sciences, Libechov, Czech Republic.
Hironori AbeDivision of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Jane L Tarry-AdkinsUniversity of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Javier Martin GonzalezTransgenic Core Facility, Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Pierre Fontanillas23andMe Inc., Sunnyvale, CA, USA.
Annique ClaringbouldStructural and Computational Biology Unit, EMBL, Heidelberg, Germany.
Olivier B BakkerUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
Patrick SulemdeCODE genetics/Amgen, Reykjavik, Iceland.
Robin G WaltersNuffield Department of Population Health, University of Oxford, Oxford, UK.
Chikashi TeraoLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Sandra TuronTransgenic Animal Unit, Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Momoko HorikoshiLaboratory for Genomics of Diabetes and Metabolism, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Kuang LinNuffield Department of Population Health, University of Oxford, Oxford, UK.
N Charlotte Onland-MoretJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Aditya SankarDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Emil Peter Thrane HertzDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Pascal N TimshelThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Vallari ShuklaDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Rehannah BorupDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kristina W OlsenDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Paula AguileraDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Mònica Ferrer-RodaGenome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Yan HuangGenome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Stasa StankovicMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Paul R H J TimmersCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Thomas U AhearnDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Behrooz Z AlizadehDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Elnaz NaderiDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Irene L AndrulisFred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
Alice M ArnoldDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Kristan J AronsonDepartment of Public Health Sciences, Queen's University, Kingston, Ontario, Canada.
Annelie AugustinssonDepartment of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
Caterina M BarbieriGenetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Robin N BeaumontGenetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Heiko BecherInstitute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Matthias W BeckmannDepartment of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Stefania BenonisdottirdeCODE genetics/Amgen, Reykjavik, Iceland.
Sven BergmannDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Murielle BochudUniversity Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.
Eric BoerwinkleHuman Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Stig E BojesenCopenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Nicholas BowkerMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Jennifer A BrodyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.
Linda BroerDepartment of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Julie E BuringBrigham and Women's Hospital, Boston, MA, USA.
Archie CampbellMedical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Harry CampbellCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Jose E CastelaoOncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Vigo, Spain.
Eulalia CatamoInstitute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Georgia Chenevix-TrenchDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Marina CiulloInstitute of Genetics and Biophysics - CNR, Naples, Italy.
Tanguy CorreDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Angela CoxSheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Laura CrisponiInstitute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.
Simon S CrossAcademic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK.
Francesco CuccaInstitute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.
Kamila CzeneKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden.
George Davey SmithMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Eco J C N de GeusDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Immaculata De VivoDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Ellen W DemerathDivision of Epidemiology & Community Health, University of Minnesotta, Minneapolis, MN, USA.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Miriam DwekSchool of Life Sciences, University of Westminster, London, UK.
Mikael ErikssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Tõnu EskoPopulation and Medical Genetics, Broad Institute, Cambridge, MA, USA.
Peter A FaschingDepartment of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Jessica D FaulSurvey Research Center, Institute for Social Research, Ann Arbor, MI, USA.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Nora FranceschiniDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Timothy M FraylingGenetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Manuela Gago-DominguezFundación Pública Galega de Medicina Xenómica, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain.
Massimo MezzavillaDepartment of Medical Sciences, University of Trieste, Trieste, Italy.
Montserrat García-ClosasDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Graham G GilesCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Harald GrallertResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Daniel F GudbjartssondeCODE genetics/Amgen, Reykjavik, Iceland.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Pascal GuénelCancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Niclas HåkanssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Per HallKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Chunyan HeDivision of Medical Oncology, Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY, USA.
Wei HeDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Gerardo HeissDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Miya K HøffdingDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Jouke J HottengaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Frank HuDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
David HunterNuffield Department of Population Health, University of Oxford, Oxford, UK.
Mohammad A IkramDepartment of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Rebecca D JacksonDepartment of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Micaella D R JoaquimGenetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Esther M JohnDepartment of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Peter K JoshiCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
David KarasikHarvard Medical School, Boston, MA, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Christiana KartsonakiNuffield Department of Population Health, University of Oxford, Oxford, UK.
Robert KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Cari M KitaharaRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Ivana KolcicFaculty of Medicine, University of Split, Split, Croatia.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Peter KraftDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Allison W KurianDepartment of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Zoltan KutalikSwiss Institute of Bioinformatics, Lausanne, Switzerland.
Martina La BiancaInstitute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy.
Genevieve LaChanceDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Joop S E LavenDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Deborah A LawlorMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Jingmei LiKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Sara LindstromDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Tricia LindstromDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Martha LinetRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
YongMei LiuCenter for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Wake Forest, NC, USA.
Simin LiuDepartment of Epidemiology, Brown University, Providence, RI, USA.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Reedik MägiEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Arto MannermaaTranslational Cancer Research Area, University of Eastern Finland, Kuopio, Finland.
Brumat MarcoDepartment of Medical Sciences, University of Trieste, Trieste, Italy.
Jonathan MartenMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Nicholas G MartinQIMR Berghofer Medical Research Insititute, Brisbane, Queensland, Australia.
Hamdi MbarekDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Barbara McKnightDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Sarah E MedlandQIMR Berghofer Medical Research Insititute, Brisbane, Queensland, Australia.
Christa MeisingerInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Thomas MeitingerInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Cristina MenniDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Andres MetspaluEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Lili MilaniEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Roger L MilneCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Grant W MontgomeryInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Antonella MulasInstitute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.
Anna M MulliganDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Alison MurrayThe Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK.
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Anne NewmanDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Raymond NoordamDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Teresa NutileInstitute of Genetics and Biophysics - CNR, Naples, Italy.
Dale R NyholtCentre for Genomics and Personalised Health, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
Andrew F OlshanDepartment of Epidemiology, Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Håkan OlssonDepartment of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.
Jodie N PainterQIMR Berghofer Medical Research Insititute, Brisbane, Queensland, Australia.
Alpa V PatelDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Natalia PerjakovaEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Annette PetersInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Paul D P PharoahCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Ozren PolasekFaculty of Medicine, University of Split, Split, Croatia.
Eleonora PorcuInstitute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.
Iffat RahmanQuantify Research, Stockholm, Sweden.
Gad RennertClalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.
Hedy S RennertClalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.
Paul M RidkerBrigham and Women's Hospital, Boston, MA, USA.
Susan M RingMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Antonietta RobinoInstitute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy.
Lynda M RoseBrigham and Women's Hospital, Boston, MA, USA.
Frits R RosendaalDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Jacques RossouwWomen's Health Initiative Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
Igor RudanCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Rico RueediDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Daniela RuggieroInstitute of Genetics and Biophysics - CNR, Naples, Italy.
Cinzia F SalaGenetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Emmanouil SaloustrosDepartment of Oncology, University Hospital of Larissa, Larissa, Greece.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Serena SannaInstitute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.
Elinor J SawyerSchool of Cancer & Pharmaceutical Sciences, Comprehensive Cancer Centre, Guy's Campus, King's College London, London, UK.
Chloé SarnowskiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
David SchlessingerNational Institute on Aging, Intramural Research Program, Baltimore, MD, USA.
Marjanka K SchmidtDivision of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Minouk J SchoemakerDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Katharina E SchrautCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Christopher ScottDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Saleh ShekariGenetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Amruta ShrikhandeDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.
Blair H SmithDivision of Population and Health Genomics, University of Dundee, Dundee, UK.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Rossella SoriceInstitute of Genetics and Biophysics - CNR, Naples, Italy.
Melissa C SoutheyCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
John J SpinelliPopulation Oncology, BC Cancer, Vancouver, British Columbia, Canada.
Meir StampferDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Doris StöcklInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Joyce B J van MeursDepartment of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Unnur StyrkarsdottirdeCODE genetics/Amgen, Reykjavik, Iceland.
Anthony J SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Lauren R TerasDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Unnur ÞorsteinsdottirdeCODE genetics/Amgen, Reykjavik, Iceland.
Nicholas J TimpsonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Daniela TonioloGenetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Michela TragliaGenetics of Common Disorders Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Melissa A TroesterDepartment of Epidemiology, Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Thérèse TruongCancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.
Jessica TyrrellGenetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
André G UitterlindenDepartment of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Sheila UliviInstitute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy.
Celine M VachonDepartment of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
Veronique VitartMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Uwe VölkerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Peter VollenweiderDepartment of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Qin WangCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Clarice R WeinbergBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
David R WeirSurvey Research Center, Institute for Social Research, Ann Arbor, MI, USA.
Amber N WilcoxDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Ko Willems van DijkDepartment of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.
Gonneke WillemsenDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
James F WilsonCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Bruce H R WolffenbuttelDepartment of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Andrew R WoodGenetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Marek ZygmuntDepartment of Obstetrics and Gynecology, University Medicine Greifswald, Greifswald, Germany.
Biobank-based Integrative Omics Study (BIOS) Consortium
eQTLGen Consortium
Biobank Japan Project
China Kadoorie Biobank Collaborative Group
kConFab Investigators
LifeLines Cohort Study
InterAct consortium
23andMe Research Team
Zhengming ChenNuffield Department of Population Health, University of Oxford, Oxford, UK.
Liming LiSchool of Public Health, Peking University Health Science Center, Beijing, P.R. China.
Lude FrankeUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
Stephen BurgessDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Patrick DeelenUniversity of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
Tune H PersThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Marie Louise GrøndahlReproductive Medicine, Department of Obstetrics and Gynaecology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
Claus Yding AndersenLaboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Anna PujolTransgenic Animal Unit, Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Andres J Lopez-ContrerasDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jeremy A DanielThe Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kari StefanssondeCODE genetics/Amgen, Reykjavik, Iceland.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Yvonne T van der SchouwJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Kathryn L LunettaDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Daniel I ChasmanBrigham and Women's Hospital, Boston, MA, USA.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Jenny A VisserDepartment of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Susan E OzanneUniversity of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Satoshi H NamekawaDivision of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Petr SolcInstitute of Animal Physiology and Genetics of the Czech Academy of Sciences, Libechov, Czech Republic.
Joanne M MurabitoNHLBI's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Ken K OngMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Eva R HoffmannDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. eva@sund.ku.dk.ORCID http://orcid.org/0000-0002-2588-0652
Anna MurrayGenetics of Human Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK. a.murray@exeter.ac.uk.ORCID http://orcid.org/0000-0002-2351-2522
Ignasi RoigGenome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain. ignasi.roig@uab.cat.ORCID http://orcid.org/0000-0003-0313-3581
John R B PerryMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK. john.perry@mrc-epid.cam.ac.uk.ORCID http://orcid.org/0000-0001-6483-3771
University of Copenhagen · DKUniversity of Cambridge · GBKarolinska Institutet · SEBrigham and Women's Hospital · USUniversity of Exeter · GBUniversitat Autònoma de Barcelona · ESErasmus MC · NLNational Institutes of Health · USdeCODE Genetics (Iceland) · ISGGD Amsterdam · NLHelmholtz Zentrum München · DEKing's College London · GBLeiden University Medical Center · NLUniversity Medical Center Groningen · NLUniversity of Washington · USWestern General Hospital · GBBoston University · USIRCCS Materno Infantile Burlo Garofolo · ITNational Research Council · ITQIMR Berghofer Medical Research Institute · AU

Funding

Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
Tissue Procurement & PathologyP50CA058223 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KATHERINE A. HOADLEY · 1992 to 2026
$59.3M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Environmental and Genetic Risk Factors For Breast Cancer: The Sister StudyZIAES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2009 to 2025
$22.7M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
The Two Sister StudyZIAES102245 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WEINBERG, CLARICE · 2009 to 2025
$8.6M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
Aging-related Traits and Disease Risk Factors in a Sardinian Population CohortZIAAG000675 · NIA · NATIONAL INSTITUTE ON AGING · PI GOROSPE, MYRIAM · 2009 to 2021
$5.7M
Women's Health Study: Infrastructure support for continued cohort follow-upU01CA182913 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 2019 to 2023
$4.0M
Cancer Control Education ProgramT32CA057726 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa B Gilkey, Melissa A. Troester · 2017 to 2026
$3.7M
DNA Damage Response Pathways in Meiotic Sex Chromosome InactivationR01GM098605 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAMEKAWA, SATOSHI · 2011 to 2020
$3.3M
Cancer Research UK 10118Cancer Research UK 16561Cancer Research UK 16563Cancer Research UK 16565Cancer Research UK 16896Cancer Research UK 29019Cancer Research UK 29186Medical Research Council G1001357Medical Research Council MC_PC_13049Medical Research Council MC_PC_14135Medical Research Council MC_PC_17189Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_U137686851Medical Research Council MC_UU_00002/7Medical Research Council MC_UU_00006/1Medical Research Council MC_UU_00006/2Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/6Medical Research Council MC_UU_00014/4Medical Research Council MC_UU_00017/1Medical Research Council MC_UU_12012/4Medical Research Council MC_UU_12015/2Medical Research Council MC_UU_12026/2NCI NIH HHS P50 CA058223NCI NIH HHS T32 CA057726NCI NIH HHS U01 CA182913NHLBI NIH HHS R01 HL105756NHLBI NIH HHS U01 HL130114NIEHS NIH HHS P30 ES010126NIGMS NIH HHS R01 GM098605Wellcome Trust 202802/Z/16/ZWellcome Trust 204623/Z/16/ZWellcome Trust 212946/Z/18/Z
6 · The paper itself

Abstract

Reproductive longevity is essential for fertility and influences healthy ageing in women

Indexed as

AdultAgingAllelesAnimalsAsia, EasternBone and BonesCheckpoint Kinase 1Checkpoint Kinase 2Diabetes Mellitus, Type 2DietEuropeFemaleFertilityFragile X Messenger Ribonucleoprotein 1Genetic Predisposition to DiseaseGenome-Wide Association StudyCheckpoint Kinase 1Checkpoint Kinase 2Chek1 protein, mouseChek2 protein, mouseFMR1 protein, humanFragile X Messenger Ribonucleoprotein 1

Identifiers

PMID34349265
PMCPMC7611832
OpenAlexW3185710912

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.