ArticleNature2021
Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 2 pooled it
12.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Chromatin state origins of uterine leiomyoma.Nature communications · 2025Pooled it
- Integrating leiomyoma genetics, epigenomics, and single-cell transcriptomics reveals causal genetic variants, genes, and cell types.Nature communications · 2024Pooled it
- POU2F1 promotes hypertensive cardiac fibrosis by regulating mitochondrial homeostasis through PINK1/Parkin‑dependent mitophagy.Molecular medicine reports · 2026Article
- Molecular insights into uterine fibroids: crosstalk between SHH and Wnt pathways, DNA methylation, and miRNAs regulation.Molecular genetics and genomics : MGG · 2026Article
- Article
- Global Burden of Premenstrual Syndrome and Uterine Fibroids in Women of Reproductive Age (1990-2023) and Projections to 2050: An Analysis of the Global Burden of Disease Study 2023.Health science reports · 2026Article
- Epigenetic Regulation of Uterine Smooth Muscle Tumors: Histone Modifications in Uterine Fibroids and Leiomyosarcoma.Biology · 2026Review
- Mechanisms of gene regulation by SRCAP and H2A.Z.Nature communications · 2026Article
- Endometrial Dysfunction in Women with Ovarian and Uterine Tumors: What Is Known and What Should Be Learned?International journal of molecular sciences · 2026Review
- Nanopore sequencing reveals hidden landscape of short L1 transductions in colorectal cancer.Communications biology · 2026Article
- Skin Epidermal Progenitor Maintenance by the SRCAP-H2A.Z Axis Downstream to Extracellular Signal-Regulated Kinase and mTOR Signaling.The Journal of investigative dermatology · 2026Article
- Decoding Bromodomain and Extra-Terminal Domain Protein-Mediated Epigenetic Mechanisms in Human Uterine Fibroids.International journal of molecular sciences · 2025Article
- Transcriptome profiling of uterine leiomyosarcomas identifies a leiomyoma-like expression pattern that indicates better survival.BJC reports · 2025Article
- IMPACTS OF DNA METHYLATION ON H2A.Z DEPOSITION AND NUCLEOSOME STABILITY.bioRxiv : the preprint server for biology · 2025Article
- Nutrition and Uterine Fibroids: Clinical Impact and Emerging Therapeutic Perspectives.Journal of clinical medicine · 2025Review
- H2A.Z reinforces maternal H3K4me3 formation and is essential for meiotic progression in mouse oocytes.Nature structural & molecular biology · 2025Article
- UTERINE FIBROIDS.Physiological reviews · 2025Review
- Klf5-adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity.Nature communications · 2025Article
- Comprehensive metabolomic and epigenomic characterization of microsatellite stable BRAF-mutated colorectal cancer.Oncogene · 2025Article
- Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 2 institutions in 1 country.
Davide G Berta *Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-0847-998X
Heli Kuisma *Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-9816-3777
Niko VälimäkiDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-9200-9560
Maritta RäisänenDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-2764-0433
Maija JänttiDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-7983-1998
Annukka PasanenDepartment of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Auli KarhuDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-7927-0796
Jaana KaukomaaDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-1183-4943
Aurora TairaDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-1179-8500
Tatiana CajusoDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-6354-5572
Sanna NieminenDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-7341-8692
Rosa-Maria PenttinenDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.
Saija AhonenDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.
Rainer LehtonenDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-8343-0318
Miika MehineDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-0443-0625
Pia VahteristoDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-4615-3825
Jyrki JalkanenDepartment of Obstetrics and Gynecology, Central Finland Central Hospital, Jyväskylä, Finland.ORCID http://orcid.org/0000-0001-7452-442X
Biswajyoti SahuApplied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-6576-5440
Janne RavanttiDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.
Netta MäkinenDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-0104-7794
Kristiina RajamäkiDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-5151-1220
Kimmo PalinDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-4621-6128
Jussi TaipaleApplied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-4204-0951
Oskari HeikinheimoDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0002-8671-130X
Ralf BützowApplied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-4366-5099
Eevi KaasinenDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland. eevi.kaasinen@helsinki.fi.ORCID http://orcid.org/0000-0002-1333-8049
Lauri A AaltonenDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland. lauri.aaltonen@helsinki.fi.ORCID http://orcid.org/0000-0001-6839-4286
University of Helsinki · FICentral Finland Health Care District · FI
Funding
No grant is acknowledged in the PubMed record.
Abstract
One in four women suffers from uterine leiomyomas (ULs)-benign tumours of the uterine wall, also known as uterine fibroids-at some point in premenopausal life. ULs can cause excessive bleeding, pain and infertility
Indexed as
Chromatin Assembly and DisassemblyMutationCarcinogenesisCell LineChromatinEmbryonic Stem CellsEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticHistonesHumansLeiomyomaLigasesPolycomb-Group ProteinsPolycomb Repressive Complex 1Transcription FactorsCBX2 protein, humanCBX4 protein, humanCBX8 protein, humanChromatinhistone H2A.F-ZHistonesLigasesPolycomb-Group ProteinsPolycomb Repressive Complex 1Transcription FactorsYEATS4 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.