Evidence map›Paper›PMID 34349220›Full record

ArticleScientific reports2021

GATA3 maintains the quiescent state of cochlear supporting cells by regulating p27

Jiadong Xu, Dongliang Yu, Xuhui Dong, Xiaoling Xie, Mei Xu, Luming Guo, Liang Huang, Qi Tang, Lin Gan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jiadong XuCollege of Life Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Dongliang YuCollege of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, 310018, Zhejiang, China.
Xuhui DongDepartment of Ophthalmology and Flaum Eye Institute, University of Rochester, Rochester, NY, 14642, USA.
Xiaoling XieDepartment of Ophthalmology and Flaum Eye Institute, University of Rochester, Rochester, NY, 14642, USA.
Mei XuCollege of Life Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Luming GuoCollege of Life Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Liang HuangDepartment of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Qi TangDepartment of Ophthalmology and Flaum Eye Institute, University of Rochester, Rochester, NY, 14642, USA.
Lin GanDepartment of Ophthalmology and Flaum Eye Institute, University of Rochester, Rochester, NY, 14642, USA. ligan@augusta.edu.
University of Rochester · USAugusta University · USPeking Union Medical College Hospital · CNZhejiang Sci-Tech University · CN

Funding

The Roles of LIM-Homeodomain Transcription Factors in Retinal DevelopmentR01EY026614 · NEI · UNIVERSITY OF ROCHESTER · PI GAN, LIN · 2016 to 2020
$1.9M
High Throughput Genomic Sequencer at BCM Core FacilityS10OD023469 · OD · BAYLOR COLLEGE OF MEDICINE · PI CHEN, RUI · 2017 to 2017
$600k
NEI NIH HHS R01 EY026614NIH HHS S10 OD023469
6 · The paper itself

Abstract

Haplo-insufficiency of the GATA3 gene causes hypoparathyroidism, sensorineural hearing loss, and renal disease (HDR) syndrome. Previous studies have shown that Gata3 is required for the development of the prosensory domain and spiral ganglion neurons (SGNs) of the mouse cochlea during embryogenesis. However, its role in supporting cells (SCs) after cell fate specification is largely unknown. In this study, we used tamoxifen-inducible Sox2

Indexed as

AnimalsCell ProliferationCochleaCyclin-Dependent Kinase Inhibitor p27Down-RegulationGATA3 Transcription FactorGene Expression Regulation, DevelopmentalMiceProtein BindingCdkn1b protein, mouseCyclin-Dependent Kinase Inhibitor p27Gata3 protein, mouseGATA3 Transcription Factor

Identifiers

PMID34349220
PMCPMC8338922
OpenAlexW3189000780

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.