Evidence map›Paper›PMID 34349200›Full record

ArticleScientific reports2021

Abnormal visual attention to simple social stimuli in 4-month-old infants at high risk for Autism.

Elisa Di Giorgio, Orsola Rosa-Salva, Elisa Frasnelli, Antonio Calcagnì, Marco Lunghi, Maria Luisa Scattoni, Francesca Simion, Giorgio Vallortigara

Registry-linked trialAbstract readComparative Study
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06915805 (BABY@NET), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06915805 recruitingnot on this mapstarted 2023, after this paper: background citation

BABY@NET: A Technology-based National Surveillance Network for the Early Identification of Autism Spectrum Disorder and Other Neurodevelopmental Disorders in At-risk Populations

TypeobservationalSponsorIstituto Superiore di SanitàRan2023 to 2025Enrolled296ConditionsAutism Spectrum Disorder (ASD), Neurodevelopmental Disorders
3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Visual function and autism spectrum disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  3. Article
  4. Research square · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Noncortical coding of biological motion in newborn chicks' brain.Cerebral cortex (New York, N.Y. : 1991) · 2024
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elisa Di GiorgioDipartimento Di Psicologia Dello Sviluppo E Della Socializzazione, Università Degli Studi Di Padova, Via Venezia 8, 35131, Padova, PD, Italy. elisa.digiorgio@unipd.it.
Orsola Rosa-SalvaCIMeC, Center for Mind/Brain Sciences, University of Trento, Mattarello, Italy.
Elisa FrasnelliSchool of Life Sciences, Lincoln University, Lincoln, UK.
Antonio CalcagnìDipartimento Di Psicologia Dello Sviluppo E Della Socializzazione, Università Degli Studi Di Padova, Via Venezia 8, 35131, Padova, PD, Italy.
Marco LunghiDipartimento Di Psicologia Dello Sviluppo E Della Socializzazione, Università Degli Studi Di Padova, Via Venezia 8, 35131, Padova, PD, Italy.
Maria Luisa ScattoniResearch Coordination and Support Service, Istituto Superiore Di Sanità, Rome, Italy.
Francesca SimionDipartimento Di Psicologia Dello Sviluppo E Della Socializzazione, Università Degli Studi Di Padova, Via Venezia 8, 35131, Padova, PD, Italy.
Giorgio VallortigaraCIMeC, Center for Mind/Brain Sciences, University of Trento, Mattarello, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite an increasing interest in detecting early signs of Autism Spectrum Disorders (ASD), the pathogenesis of the social impairments characterizing ASD is still largely unknown. Atypical visual attention to social stimuli is a potential early marker of the social and communicative deficits of ASD. Some authors hypothesized that such impairments are present from birth, leading to a decline in the subsequent typical functioning of the learning-mechanisms. Others suggested that these early deficits emerge during the transition from subcortically to cortically mediated mechanisms, happening around 2-3 months of age. The present study aimed to provide additional evidence on the origin of the early visual attention disturbance that seems to characterize infants at high risk (HR) for ASD. Four visual preference tasks were used to investigate social attention in 4-month-old HR, compared to low-risk (LR) infants of the same age. Visual attention differences between HR and LR infants emerged only for stimuli depicting a direct eye-gaze, compared to an adverted eye-gaze. Specifically, HR infants showed a significant visual preference for the direct eye-gaze stimulus compared to LR infants, which may indicate a delayed development of the visual preferences normally observed at birth in typically developing infants. No other differences were found between groups. Results are discussed in the light of the hypotheses on the origins of early social visual attention impairments in infants at risk for ASD.

Indexed as

Age FactorsAttentionAutism Spectrum DisorderFixation, OcularHumansInfantInfant, NewbornLearningRisk

Identifiers

PMID34349200
PMCPMC8338945

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.