ArticleScientific reports2021
Neonicotinoids can cause arrested pupal ecdysis in Lepidoptera.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Beyond Standard Protocols: Advanced Patented Technology for Comprehensive Toxicity Assessments in Neotropical Bees.Toxics · 2026Article
- Combined effects of a pyrethroid insecticide and azole fungicide on lepidopteran growth analysed with DEB-TKTD modelling.Ecotoxicology (London, England) · 2025Article
- Review
- Using insecticidal compounds to elucidate the potential role of neurotransmitters in Lepidoptera pupal ecdysis.Scientific reports · 2025Article
- Neonicotinoid Insecticides can Enhance Milkweed Vigor and Subsequently Impact Monarch Performance.Journal of chemical ecology · 2025Article
- [Determination of eight neonicotinoid pesticides in wastewater by solid phase extraction combined with liquid chromatography-tandem mass spectrometry].Se pu = Chinese journal of chromatography · 2024Article
- Discovering allatostatin type-C receptor specific agonists.Nature communications · 2024Article
- Review
- Long-term exposure to environmental concentration of dinotefuran disrupts ecdysis and sex ratio by dysregulating related gene expressions inFrontiers in endocrinology · 2024Article
- Larvicidal activity of Stemona collinsiae root extract against Musca domestica and Chrysomya megacephala.Scientific reports · 2023Article
- Gene expression in bumble bee larvae differs qualitatively between high and low concentration imidacloprid exposure levels.Scientific reports · 2023Article
- Monarch Butterfly Ecology, Behavior, and Vulnerabilities in North Central United States Agricultural Landscapes.Bioscience · 2022Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, we reported a novel mode of action in monarch butterfly (Danaus plexippus) larvae exposed to neonicotinoid insecticides: arrest in pupal ecdysis following successful larval ecdysis. In this paper, we explore arrested pupal ecdysis in greater detail and propose adverse outcome pathways to explain how neonicotinoids cause this effect. Using imidacloprid as a model compound, we determined that final-instar monarchs, corn earworms (Helicoverpa zea), and wax moths (Galleria mellonella) showed high susceptibility to arrested pupal ecdysis while painted ladies (Vanessa cardui) and red admirals (Vanessa atalanta) showed low susceptibility. Fall armyworms (Spodoptera frugiperda) and European corn borers (Ostrinia nubilalis) were recalcitrant. All larvae with arrested ecdysis developed pupal cuticle, but with incomplete shedding of larval cuticle and unexpanded pupal appendages; corn earworm larvae successfully developed into adults with unexpanded appendages. Delayed initiation of pupal ecdysis was also observed with treated larvae. Imidacloprid exposure was required at least 26 h prior to pupal ecdysis to disrupt the molt. These observations suggest neonicotinoids may disrupt the function of crustacean cardioactive peptide (CCAP) neurons, either by directly acting on their nicotinic acetylcholine receptors or by acting on receptors of inhibitory neurons that regulate CCAP activity.
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