ArticleNature communications2021
Vertically transferred maternal immune cells promote neonatal immunity against early life infections.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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Who cites it
44 citing papers in PubMed, 83 citations in OpenAlex.
- Development of in-house PCR assays and cross-sectional molecular surveillance of infectious pathogens in adverse pregnancy outcomes and neonatal sepsis in central India.BMC infectious diseases · 2026Article
- Maternal microchimerism at birth associates with reduced odds of non-malarial fever and respiratory tract infections in Tanzanian children.PLOS global public health · 2026Article
- Prenatal maternal infection promotes maternal microchimeric cells to alter infection risk in male offspring.Frontiers in immunology · 2026Article
- Dissecting infant and maternal antibody repertoires exposes the early onset of infant humoral immunity.Clinical & translational immunology · 2026Article
- Identifying Key Questions and Challenges in Microchimerism Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- "Microbial and immune modulation by 2'-fucosyllactose supplementation during gestation: a strategy to prevent food allergies".Gut microbes · 2025Article
- Article
- Micro-chimerism: from evolution to revolution.Seminars in immunopathology · 2025Article
- Immune control of brain physiology.Nature reviews. Immunology · 2025Review
- Chimerism and immunological tolerance in solid organ transplantation.Seminars in immunopathology · 2025Review
- Ascending Vaginal Infection in Mice Induces Preterm Birth and Neonatal Morbidity.The American journal of pathology · 2025Article
- Exposure to Human Immunodeficiency Virus Is Associated With Altered Composition of Maternal Microchimeric T Cells in Infants.The Journal of infectious diseases · 2025Article
- Micro-to multi-chimerism: the multiple facets of a singular phenomenon.Seminars in immunopathology · 2025Review
- Quantitative and longitudinal assessment of human placental inflammation using diffusion basis spectrum imaging.npj women's health · 2025Article
- Lung stem cells and respiratory epithelial chimerism in transplantation.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Number of tetanus toxoid injections before birth and associated factors among pregnant women in low and middle income countries: Negative binomial poisson regression.Human vaccines & immunotherapeutics · 2024Review
- Maternal immune activation does not affect maternal microchimeric cells.Biology open · 2024Article
- Clinical relevance of feto-maternal microchimerism in (hematopoietic stem cell) transplantation.Seminars in immunopathology · 2024Review
- Parent-Specific Transgenerational Immune Priming Enhances Offspring Defense-Unless Heat Stress Negates It All.Ecology and evolution · 2024Article
- Deciphering the Role of Maternal Microchimerism in Offspring Autoimmunity: A Narrative Review.Medicina (Kaunas, Lithuania) · 2024Review
Corrections and comments
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Authors and funding
17 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During mammalian pregnancy, immune cells are vertically transferred from mother to fetus. The functional role of these maternal microchimeric cells (MMc) in the offspring is mostly unknown. Here we show a mouse model in which MMc numbers are either normal or low, which enables functional assessment of MMc. We report a functional role of MMc in promoting fetal immune development. MMc induces preferential differentiation of hematopoietic stem cells in fetal bone marrow towards monocytes within the myeloid compartment. Neonatal mice with higher numbers of MMc and monocytes show enhanced resilience against cytomegalovirus infection. Similarly, higher numbers of MMc in human cord blood are linked to a lower number of respiratory infections during the first year of life. Our data highlight the importance of MMc in promoting fetal immune development, potentially averting the threats caused by early life exposure to pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.