ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
G-Protein-Coupled Estrogen Receptor (GPER) in the Rostral Ventromedial Medulla Is Essential for Mobilizing Descending Inhibition of Itch.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- GPER in murine astrocytes and mural cells promotes neurovascular coupling and Aβ clearance.Research square · 2026Article
- Supraspinal Circuit Mechanisms Underlying Itch Processing.CNS neuroscience & therapeutics · 2026Review
- Reviewing the Peripheral and Central Mechanisms of Visceral Hypersensitivity in Intestinal Disorders.International journal of medical sciences · 2026Review
- Central neural circuits underlying itch sensation.Nature reviews. Neuroscience · 2025Review
- An intra-brainstem circuitry for pain-induced inhibition of itch.Neuroscience · 2025Article
- Orexin neurons play contrasting roles in itch and pain neural processing via projecting to the periaqueductal gray.Communications biology · 2024Article
- Molecular identification of bulbospinal ON neurons by GPER, which drives pain and morphine tolerance.The Journal of clinical investigation · 2023Article
- Article
- The chronification mechanism of orofacial inflammatory pain: Facilitation by GPER1 and microglia in the rostral ventral medulla.Frontiers in molecular neuroscience · 2022Article
- A neuropeptide code for itch.Nature reviews. Neuroscience · 2021Review
- Optotagging and characterization of GABAergic rostral ventromedial medulla (RVM) neurons.Molecular painArticle
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
Chronic itch is a troublesome condition and often difficult to cure. Emerging evidence suggests that the periaqueductal gray (PAG)-rostral ventromedial medulla (RVM) pathway may play an important role in the regulation of itch, but the cellular organization and molecular mechanisms remain incompletely understood. Here, we report that a group of RVM neurons distinctively express the G-protein-coupled estrogen receptor (GPER), which mediates descending inhibition of itch. We found that GPER
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.