Evidence map›Paper›PMID 34348994›Full record

ArticleMolecular cancer research : MCR2021

Monoallelic IDH1 R132H Mutation Mediates Glioma Cell Response to Anticancer Therapies via Induction of Senescence.

Daqian Zhan, Ding Ma, Shuang Wei, Bachchu Lal, Yi Fu, Charles Eberhart, John Laterra, Mingyao Ying, Yunqing Li, Alan Meeker and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Lipid and glucose metabolism in senescence.Frontiers in nutrition · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Daqian Zhan *Neurology, Hugo W. Moser Research Institute at Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Ding Ma *Neurology, Hugo W. Moser Research Institute at Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Shuang WeiDepartment of Respiratory and Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Bachchu LalNeurology, Hugo W. Moser Research Institute at Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Yi FuNeurology, Hugo W. Moser Research Institute at Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Charles EberhartDepartment of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
John LaterraNeurology, Hugo W. Moser Research Institute at Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Mingyao YingNeurology, Hugo W. Moser Research Institute at Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-6215-4959
Yunqing LiNeurology, Hugo W. Moser Research Institute at Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Alan MeekerDepartments of Oncology, Pathology, Urology, Sidney Kimmel Comprehensive Cancer Center, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Hernando Lopez-BertoniNeurology, Hugo W. Moser Research Institute at Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. xia@kennedykrieger.org LopezBertoni@kennedykrieger.org.ORCID 0000-0001-6618-1092
Shuli XiaNeurology, Hugo W. Moser Research Institute at Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. xia@kennedykrieger.org LopezBertoni@kennedykrieger.org.
Kennedy Krieger Institute · USJohns Hopkins University · USHuazhong University of Science and Technology · CN

Funding

Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
Chromatin Modifications in GBM-Propagating CellsR01NS096754 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI LATERRA, JOHN J · 2017 to 2021
$2.2M
Molecular determinants of cellular heterogeneity and therapeutic resistance in GBM.R01NS120949 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI LOPEZ-BERTONI, HERNANDO MARTIN · 2021 to 2025
$2.0M
Methyl-CpG-dependent transcription factor function in human gliomaR01NS091165 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI XIA, SHULI · 2015 to 2019
$1.8M
Targeting Hyaluronan-mediated Motility Receptor in Glioblastoma Stem CellsR01NS099460 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI YING, MINGYAO · 2017 to 2021
$1.8M
Tet2 regulation and function in glioma cell phenotype reprogrammingR01NS110087 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI LATERRA, JOHN J · 2019 to 2023
$1.8M
Suppression of Glioblastoma Stem Cells by Kruppel-Like Factor 9R01NS076759 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI LATERRA, JOHN J · 2011 to 2015
$1.6M
NICHD NIH HHS P50 HD103538NINDS NIH HHS R01 NS076759NINDS NIH HHS R01 NS091165NINDS NIH HHS R01 NS096754NINDS NIH HHS R01 NS099460NINDS NIH HHS R01 NS110087NINDS NIH HHS R01 NS120949
6 · The paper itself

Abstract

Heterozygous isocitrate dehydrogenase (IDH) R132H mutation (IDH1

Indexed as

AnimalsCell Line, TumorCell ProliferationCellular SenescenceFemaleGliomaHumansIsocitrate DehydrogenaseMiceMice, SCIDMutationNeoplasmsTumor MicroenvironmentIsocitrate Dehydrogenase

Identifiers

PMID34348994
PMCPMC8568642
OpenAlexW3192119376

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.