ReviewEuropean respiratory review : an official journal of the European Respiratory Society2021
Airway granulation response to lung-implantable medical devices: a concise overview.
Review in European respiratory review : an official journal of the European Respiratory Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Extrapulmonary effects of lung volume reduction in severe emphysema: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Adverse Events of Tracheobronchial Stents: A MAUDE Database Study With Focus on Metallic Stents.Laryngoscope investigative otolaryngology · 2026Article
- Effect of PEEP mask on cough in patients with tracheobronchomalacia.BMC pulmonary medicine · 2026Article
- Immunophenotypic and structural signatures of severe granulation tissue in airway implant patients.Respiratory research · 2026Article
- Airway Malacia: Stent Innovations and Emerging Ex Vivo Testing Platforms.Seminars in thoracic and cardiovascular surgery. Pediatric cardiac surgery annual · 2026Review
- Comparative Analysis of Metagenomic Next-Generation Sequencing and Conventional Culture for Pathogen Detection in 218 Patients with Pulmonary Infectious Diseases: A Retrospective Study.Infection and drug resistance · 2026Article
- Lung implantable devices: the issue with granulation tissue.Breathe (Sheffield, England) · 2025Article
- Systemic pro-inflammatory response following bronchoscopic lung volume reduction using endobronchial valves.ERJ open research · 2025Article
- Anti-inflammatory coupled anti-angiogenic airway stent effectively suppresses tracheal in-stents restenosis.Journal of nanobiotechnology · 2025Article
- Successful Treatment of Obstructive Pneumonia with Hemoptysis due to Non-Absorbable Suture-Related Granulation.Surgical case reports · 2025Article
- Respiratory endoscopy intervention in 12 patients with refractory persistent air leakage after pulmonary surgery: a preliminary study of case series.Journal of cardiothoracic surgery · 2024Article
- Surgical and bronchoscopic pulmonary function-improving procedures in lung emphysema.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- External beam radiotherapy inhibits stent related granulation hyperplasia in rabbit trachea.Scientific reports · 2023Article
- Vancomycin-Loaded Polycaprolactone Electrospinning Nanofibers Modulate the Airway Interfaces to Restrain Tracheal Stenosis.Frontiers in bioengineering and biotechnology · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing numbers of endoscopically implantable devices are implanted in the airways, such as airway stents, one-way valves and coils, to treat both malignant and benign diseases. They significantly improve patient outcomes, but their long-term effectiveness and sustainability is hampered by the reaction of the formation of granulation tissue. Factors including procedural-related tissue injury; micro-organism presence; device-related factors, such as the material, design and sizing in relation to the airway; and patient-related factors, including genetic susceptibility, comorbidities and medication use, might all effect the severity of the tissue response and the subsequent degree of granulation tissue formation. However, research into the underlying mechanism and risk factors is scarce and therefore our knowledge is limited. Joint efforts from the scientific community, both pre-clinical and clinical, are needed to gain a deeper understanding and eventually improve the long-term treatment effectiveness of lung-implantable devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.