Evidence map›Paper›PMID 34348976›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

STAT5 Represses a STAT3-Independent Th17-like Program during Th9 Cell Differentiation.

D Alejandro Canaria, Bingyu Yan, Maia G Clare, Zonghao Zhang, Grace A Taylor, David L Boone, Majid Kazemian, Matthew R Olson

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
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  5. Article
  6. Article
  7. Effects ofMicroorganisms · 2023
    Article
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  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

D Alejandro CanariaDepartment of Biological Sciences, Purdue University, West Lafayette, IN.ORCID 0000-0002-1657-9120
Bingyu YanDepartment of Biochemistry, Purdue University, West Lafayette, IN.ORCID 0000-0003-4429-8200
Maia G ClareDepartment of Biological Sciences, Purdue University, West Lafayette, IN.ORCID 0000-0002-7632-6192
Zonghao ZhangDepartment of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN.ORCID 0000-0002-3744-2035
Grace A TaylorDepartment of Biological Sciences, Purdue University, West Lafayette, IN.
David L BooneDepartment of Microbiology and Immunology, Indiana University School of Medicine, South Bend, IN; and.
Majid KazemianDepartment of Biochemistry, Purdue University, West Lafayette, IN.ORCID 0000-0001-7080-8820
Matthew R OlsonDepartment of Biological Sciences, Purdue University, West Lafayette, IN; olson126@purdue.edu.
Purdue University West Lafayette · USIndiana University South Bend · US

Funding

A role for the stomach in protection from colitisR01DK124304 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI BOONE, DAVID L. · 2020 to 2023
$2.0M
Joint submission for administrative supplement proposal: HIPAA aligned storage and computing solutionR35GM138283 · NIGMS · PURDUE UNIVERSITY · PI KAZEMIAN, MAJID · 2020 to 2024
$2.0M
A new model of ILC3-independent innate colitisR01DK120320 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI BOONE, DAVID L. · 2019 to 2021
$1.0M
NIDDK NIH HHS R01 DK120320NIDDK NIH HHS R01 DK124304NIGMS NIH HHS R35 GM138283
6 · The paper itself

Abstract

IL-9-producing Th cells, termed Th9 cells, contribute to immunity against parasites and cancers but have detrimental roles in allergic disease and colitis. Th9 cells differentiate in response to IL-4 and TGF-β, but these signals are insufficient to drive Th9 differentiation in the absence of IL-2. IL-2-induced STAT5 activation is required for chromatin accessibility within

Indexed as

STAT5 Transcription FactorTh17 CellsAnimalsCell DifferentiationGene Expression RegulationHumansInterleukin-9MiceSTAT3 Transcription FactorInterleukin-9STAT3 protein, humanSTAT3 Transcription FactorSTAT5 Transcription Factor

Identifiers

PMID34348976
PMCPMC8387395
OpenAlexW3191763313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.