Evidence map›Paper›PMID 34348785›Full record

ArticleActa neuropathologica communications2021

Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice.

Cristina Cudalbu, Pierre Bady, Marta Lai, Lijing Xin, Olga Gusyatiner, Marie-France Hamou, Mario Lepore, Jean-Philippe Brouland, Roy T Daniel, Andreas F Hottinger and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Review
  3. Elevated glioma-related cortical glutamateBrain communications · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Cristina Cudalbu *CIBM Center for Biomedical Imaging, Lausanne, Switzerland.
Pierre Bady *Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.
Marta LaiCIBM Center for Biomedical Imaging, Lausanne, Switzerland.
Lijing XinCIBM Center for Biomedical Imaging, Lausanne, Switzerland.
Olga GusyatinerNeuroscience Research Center, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Marie-France HamouNeuroscience Research Center, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Mario LeporeCIBM Center for Biomedical Imaging, Lausanne, Switzerland.
Jean-Philippe BroulandInstitute of Pathology, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Roy T DanielNeurosurgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Andreas F Hottinger *Neuroscience Research Center, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Monika E Hegi *Neuroscience Research Center, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland. monika.hegi@chuv.ch.ORCID 0000-0003-0855-6495
Centre d'Imagerie BioMedicale · CHUniversity of Lausanne · CHSIB Swiss Institute of Bioinformatics · CHSwiss Cancer Center Léman · CHUniversity Hospital of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The invasive behavior of glioblastoma, the most aggressive primary brain tumor, is considered highly relevant for tumor recurrence. However, the invasion zone is difficult to visualize by Magnetic Resonance Imaging (MRI) and is protected by the blood brain barrier, posing a particular challenge for treatment. We report biological features of invasive growth accompanying tumor progression and invasion based on associated metabolic and transcriptomic changes observed in patient derived orthotopic xenografts (PDOX) in the mouse and the corresponding patients' tumors. The evolution of metabolic changes, followed in vivo longitudinally by

Indexed as

AdultAgedAnimalsBrain NeoplasmsFemaleGlioblastomaHumansMagnetic Resonance ImagingMaleMetabolomeMiceMiddle AgedNeoplasm InvasivenessNeoplasm TransplantationProton Magnetic Resonance SpectroscopyTranscriptome1H MRS at ultra-high fields (UHF)GlioblastomaInvasionPatient-derived orthotopic xenografts (PDOX)TranscriptomeTumor host interaction

Identifiers

PMID34348785
PMCPMC8336020
OpenAlexW3193071789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.