Evidence map›Paper›PMID 34348736›Full record

ArticleParticle and fibre toxicology2021

Titanium dioxide nanoparticles enhance thrombosis through triggering the phosphatidylserine exposure and procoagulant activation of red blood cells.

Yiying Bian, Han-Young Chung, Ok-Nam Bae, Kyung-Min Lim, Jin-Ho Chung, Jingbo Pi

Open access · goldAbstract read
In one paragraph

Article in Particle and fibre toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cardiovascular Toxicity of Metal-Based Nanoparticles.International journal of molecular sciences · 2025
    Review
  7. Subchronic Inhalation of TiOJournal of applied toxicology : JAT · 2025
    Article
  8. Review
  9. Biomedical application of TiOCell biology and toxicology · 2024
    Article
  10. Review
  11. Article
  12. Food-Grade Titanium Dioxide Induces Toxicity in the NematodeNanomaterials (Basel, Switzerland) · 2022
    Article
  13. Raman Spectroscopic Study of TiOMaterials (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Yiying BianSchool of Public Health, China Medical University, Shenyang, 110122, People's Republic of China. byy19900719@snu.ac.kr.
Han-Young ChungDepartment of Agricultural Biotechnology, and Center for Food Safety and Toxicology, Seoul National University, Seoul, 151-742, South Korea.
Ok-Nam BaeCollege of Pharmacy, Hanyang University, Ansan, Gyeonggido, 426-791, South Korea.
Kyung-Min LimCollege of Pharmacy, Ewha Womans University, Seoul, 120-750, South Korea.
Jin-Ho ChungCollege of Pharmacy, Seoul National University, Seoul, 151-742, South Korea. jhc302@snu.ac.kr.ORCID 0000-0002-7248-2980
Jingbo PiSchool of Public Health, China Medical University, Shenyang, 110122, People's Republic of China. jbpi@cmu.edu.cn.
China Medical University · CNSeoul National University · KREwha Womans University · KRHanyang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExpanding biomedical application of anatase titanium dioxide (TiO

resultsWe conducted in vitro studies using RBCs freshly isolated from healthy male volunteers. TiO

conclusionCollectively, these results suggest that anatase TiO

Indexed as

NanoparticlesThrombosisAnimalsEndothelial CellsErythrocytesMalePhosphatidylserinesRatsTitaniumPhosphatidylserinesTitaniumtitanium dioxidePhosphatidylserine (PS) exposureProcoagulant activityRed blood cells (RBCs)ThrombosisTitanium dioxide nanoparticles (TiO2 NPs)

Identifiers

PMID34348736
PMCPMC8336274
OpenAlexW3188469175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.