ArticleBiomedical engineering online2021
Thymoquinone loading into hydroxyapatite/alginate scaffolds accelerated the osteogenic differentiation of the mesenchymal stem cells.
Article in Biomedical engineering online, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Recent Advancements in Non-surgical Approaches for the Management of Delayed Union and Nonunion in Long Bone Fractures of the Extremities: A Review.Advances in therapy · 2026Review
- Exploring In Vitro Mesenchymal Stem Cell Osteodifferentiation via Vibrational Microspectroscopy: A Review.Stem cell reviews and reports · 2025Review
- Biomimetic Polyurethanes in Tissue Engineering.Biomimetics (Basel, Switzerland) · 2025Review
- Strontium-doped hydroxyapatite microspheres loaded with iloprost promote dentin-pulp complex regeneration.Frontiers in bioengineering and biotechnology · 2025Article
- Natural bioactive compounds modified with mesenchymal stem cells: new hope for regenerative medicine.Frontiers in bioengineering and biotechnology · 2025Review
- Moldable Alginate/Hydroxyapatite Hydrogel Loaded with Metformin Enhanced Regeneration of the Rabbit Mandibular Defects.Journal of maxillofacial and oral surgery · 2024Article
- pH-sustaining nanostructured hydroxyapatite/alginate composite hydrogel for gastric protection and intestinal release ofBioengineering & translational medicine · 2023Article
- The healing effects of thymoquinone on experimentally induced traumatic tendinopathy in rabbits.Journal of orthopaedic surgery and research · 2023Article
- The Effects of Thymoquinone Loaded in Alginate Scaffold on Bone Regeneration in Rabbit Mandible Defect.Galen medical journal · 2023Article
- Utilization of Nanotechnology to Improve Bone Health in Osteoporosis ExploitingBioengineering (Basel, Switzerland) · 2022Review
- Progress of Polysaccharide-Contained Polyurethanes for Biomedical Applications.Tissue engineering and regenerative medicine · 2022Review
- Accelerating effect of Shilajit on osteogenic property of adipose-derived mesenchymal stem cells (ASCs).Journal of orthopaedic surgery and research · 2022Article
- Expression and ratio of receptor activator of nuclear factor kappa-B ligand and osteoprotegerin following application ofJournal of Indian Prosthodontic SocietyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPhytochemical agents such as thymoquinone (TQ) have osteogenic property. This study aimed to investigate the synergic impact of TQ and hydroxyapatite on mesenchymal stem cell differentiation. Alginate was also used as drug vehicle.
methodsHA scaffolds were fabricated by casting into polyurethane foam and sintering at 800 °C, and then, 1250 °C and impregnated by TQ containing alginate. The adipose-derived stem cells were aliquoted into 4 groups: control, osteogenic induced-, TQ and osteogenic induced- and TQ-treated cultures. Adipose derived-mesenchymal stem cells were mixed with alginate and loaded into the scaffolds
resultsThe results showed that impregnation of HA scaffold with alginate decelerated the degradation rate and reinforced the mechanical strength. TQ loading in alginate/HA had no significant influence on physical and mechanical properties. Real-time RT-PCR showed significant elevation in collagen, osteopontin, and osteocalcin expression at early phase of differentiation. TQ also led to an increase in alkaline phosphatase activity. At long term, TQ administration had no impact on calcium deposition and proliferation rate as well as bone-marker expression.
conclusionTQ accelerates the differentiation of the stem cells into the osteoblasts, without changing the physical and mechanical properties of the scaffolds. TQ also showed a synergic influence on differentiation potential of mesenchymal stem cells.
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