ArticleBMC genomics2021
Increased abundance of secreted hydrolytic enzymes and secondary metabolite gene clusters define the genomes of latent plant pathogens in the Botryosphaeriaceae.
Article in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Genome-Wide Characterization of thePlants (Basel, Switzerland) · 2026Article
- Species-Specific Pathogens Drive Distinct Structural and Inter-Kingdom Dynamics in the Mulberry Leaf Microbiome.Microorganisms · 2026Article
- Lineage-Specific Gene Family Innovations Underpin the Pathogenicity of Woody-Plant Pathogens in Botryosphaeriaceae.Genome biology and evolution · 2026Article
- Machine-Learning Prediction of Extracellular Vesicle Protein Sorting Expands the Characterization of Secretory Functions inJournal of fungi (Basel, Switzerland) · 2026Article
- Isolation and Identification of Pathogens Associated with Fruit Rot ofMicroorganisms · 2026Article
- Comprehensive pan-effectome investigation reveals central effector genes in woody plant pathogen Botryosphaeriaceae.Applied and environmental microbiology · 2026Article
- Flavin-Containing Monooxygenase 1 Gene Mediates Resistance toPlants (Basel, Switzerland) · 2026Article
- Chromosome-level genome assemblies for the latent pine pathogen, Diplodia sapinea, reveal two accessory chromosomes with distinct genomic features and evolutionary dynamics.G3 (Bethesda, Md.) · 2025Article
- The dark side of avocados: a review of anthracnose and stem-end rot in postharvest fruit.Frontiers in microbiology · 2025Review
- Genome-wide survey of the bipartite structure and pathogenesis-related genes ofFrontiers in microbiology · 2024Article
- Comparative genomics of the extremophileFrontiers in fungal biology · 2024Article
- Plant-AssociatedJournal of fungi (Basel, Switzerland) · 2023Review
- Genome Sequencing and Analysis Reveal Potential High-Valued Metabolites Synthesized byJournal of fungi (Basel, Switzerland) · 2023Article
- In Silico Characterization of the Secretome of the Fungal PathogenJournal of fungi (Basel, Switzerland) · 2023Article
- Fungal Secondary Metabolites and Small RNAs Enhance Pathogenicity during Plant-Fungal Pathogen Interactions.Journal of fungi (Basel, Switzerland) · 2022Review
- Unveiling the Secretome of the Fungal Plant PathogenJournal of fungi (Basel, Switzerland) · 2022Article
- Pathogenicity Factors of Botryosphaeriaceae Associated with Grapevine Trunk Diseases: New Developments on Their Action on Grapevine Defense Responses.Pathogens (Basel, Switzerland) · 2022Review
- Genome Analyses of Two Blueberry Pathogens:Journal of fungi (Basel, Switzerland) · 2022Article
- Water Deficit Timing Differentially Affects Physiological Responses of Grapevines Infected withPlants (Basel, Switzerland) · 2022Article
- Comparative Genomics Reveals Evolutionary Traits, Mating Strategies, and Pathogenicity-Related Genes Variation ofFrontiers in microbiology · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Botryosphaeriaceae are important plant pathogens, but also have the ability to establish asymptomatic infections that persist for extended periods in a latent state. In this study, we used comparative genome analyses to shed light on the genetic basis of the interactions of these fungi with their plant hosts. For this purpose, we characterised secreted hydrolytic enzymes, secondary metabolite biosynthetic gene clusters and general trends in genomic architecture using all available Botryosphaeriaceae genomes, and selected Dothideomycetes genomes.
resultsThe Botryosphaeriaceae genomes were rich in carbohydrate-active enzymes (CAZymes), proteases, lipases and secondary metabolic biosynthetic gene clusters (BGCs) compared to other Dothideomycete genomes. The genomes of Botryosphaeria, Macrophomina, Lasiodiplodia and Neofusicoccum, in particular, had gene expansions of the major constituents of the secretome, notably CAZymes involved in plant cell wall degradation. The Botryosphaeriaceae genomes were shown to have moderate to high GC contents and most had low levels of repetitive DNA. The genomes were not compartmentalized based on gene and repeat densities, but genes of secreted enzymes were slightly more abundant in gene-sparse regions.
conclusionThe abundance of secreted hydrolytic enzymes and secondary metabolite BGCs in the genomes of Botryosphaeria, Macrophomina, Lasiodiplodia, and Neofusicoccum were similar to those in necrotrophic plant pathogens and some endophytes of woody plants. The results provide a foundation for comparative genomic analyses and hypotheses to explore the mechanisms underlying Botryosphaeriaceae host-plant interactions.
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