ArticleJournal of the American Heart Association2021
Rheumatic Heart Disease in the United States: Forgotten But Not Gone: Results of a 10 Year Multicenter Review.
Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 38 citations in OpenAlex.
- Acute rheumatic fever and rheumatic heart disease in Latin America: a contemporary review of epidemiology.Lancet regional health. Americas · 2026Review
- An echocardiographic appreciation of rheumatic heart disease: phenotypic variability of valvular involvement and its prognostic implications.Lancet regional health. Americas · 2026Review
- Article
- Epidemiology and determinants of cardiovascular disease in Indigenous populations.Nature reviews. Cardiology · 2026Review
- Inequities in Indigenous Youth with Rheumatic Fever in the USA: A Single-Center Study.Journal of racial and ethnic health disparities · 2026Article
- Myocarditis Following Invasive Group ACase reports in infectious diseases · 2026Article
- The "Cairo Accord"- towards the eradication of RHD: revisited (2026).Frontiers in cardiovascular medicine · 2026Review
- Global burden of rheumatic vs non-rheumatic valvular heart disease, 1990-2021: a systematic analysis of the global burden of disease study.Clinical rheumatology · 2025Article
- Article
- Acute Rheumatic Fever in Caucasians: A Case Report and Systematic Review.Life (Basel, Switzerland) · 2025Article
- Rheumatic heart valve disease: navigating the challenges of an overlooked autoimmune disorder.Frontiers in cardiovascular medicine · 2025Review
- Expression profiles and bioinformatic analysis of circular RNA in rheumatic heart disease: potential hsa_circ_0001490 and hsa_circ_0001296 as a diagnostic biomarker.Frontiers in cardiovascular medicine · 2025Article
- Rheumatic Heart Disease Burden: A Comparative Analysis between the United States and the European Union.JACC. Advances · 2024Article
- Acute on Chronic Rheumatic Valvulitis.JACC. Case reports · 2024Article
- Temporal trend analysis of rheumatic heart disease burden in high-income countries between 1990 and 2019.European heart journal. Quality of care & clinical outcomes · 2024Article
- Article
- Identifying genetic determinants of Streptococcus pyogenes-host interactions in a murine intact skin infection model.Cell reports · 2023Article
- Rheumatic Heart Disease in the Developing World.Structural heart : the journal of the Heart Team · 2023Review
- Development and User Testing of a Dynamic Tool for Rheumatic Heart Disease Management.Applied clinical informatics · 2023Article
- Pathogenesis, epidemiology and control of Group A Streptococcus infection.Nature reviews. Microbiology · 2023Review
Corrections and comments
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Authors and funding
38 authors at 20 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Recent evaluation of rheumatic heart disease (RHD) mortality demonstrates disproportionate disease burden within the United States. However, there are few contemporary data on US children living with acute rheumatic fever (ARF) and RHD. Methods and Results Twenty-two US pediatric institutions participated in a 10-year review (2008-2018) of electronic medical records and echocardiographic databases of children 4 to 17 years diagnosed with ARF/RHD to determine demographics, diagnosis, and management. Geocoding was used to determine a census tract-based socioeconomic deprivation index. Descriptive statistics of patient characteristics and regression analysis of RHD classification, disease severity, and initial antibiotic prescription according to community deprivation were obtained. Data for 947 cases showed median age at diagnosis of 9 years; 51% and 56% identified as male and non-White, respectively. Most (89%) had health insurance and were first diagnosed in the United States (82%). Only 13% reported travel to an endemic region before diagnosis. Although 96% of patients were prescribed secondary prophylaxis, only 58% were prescribed intramuscular benzathine penicillin G. Higher deprivation was associated with increasing disease severity (odds ratio, 1.25; 95% CI, 1.08-1.46). Conclusions The majority of recent US cases of ARF and RHD are endemic rather than the result of foreign exposure. Children who live in more deprived communities are at risk for more severe disease. This study demonstrates a need to improve guideline-based treatment for ARF/RHD with respect to secondary prophylaxis and to increase research efforts to better understand ARF and RHD in the United States.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.