Evidence map›Paper›PMID 34348471›Full record

Observational studyJournal of the American Heart Association2021

Domains of Physical Activity in Relation to Stiffness Index in the General Population.

Natalie Arnold, Arne Deiseroth, Omar Hahad, Simon Diestelmeier, Andreas Schulz, Andrea Daubenbüchel, Tommaso Gori, Harald Binder, Norbert Pfeiffer, Jürgen Prochaska and 4 more

Open access · goldAbstract readComparative StudyObservational Study
In one paragraph

Observational study in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. The physical activity health paradox: what is it, why might it happen, and where to go from here?The international journal of behavioral nutrition and physical activity · 2026
    Review
  2. Physical Activity and Arterial Stiffness: A Narrative Review.Journal of clinical hypertension (Greenwich, Conn.) · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Natalie ArnoldDepartment of Cardiology Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Arne DeiserothDepartment of Sport, Exercise and Health University of Basel Switzerland.
Omar HahadDepartment of Cardiology Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Simon DiestelmeierDepartment of Cardiology Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Andreas SchulzDepartment of Cardiology Preventive Cardiology and Preventive Medicine University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Andrea DaubenbüchelDepartment of Cardiology Preventive Cardiology and Preventive Medicine University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Tommaso GoriDepartment of Cardiology Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Harald BinderInstitute of Medical Biostatistics, Epidemiology and Informatics (IMBEI)University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Norbert PfeifferDepartment of Ophthalmology University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Jürgen ProchaskaDepartment of Cardiology Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Manfred BeutelDepartment of Psychosomatic Medicine and Psychotherapy University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Karl J LacknerDZHK (German Center for Cardiovascular Research) Partner Site Rhine-Main Mainz Germany.
Thomas MünzelDepartment of Cardiology Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Philipp S WildDepartment of Cardiology Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.
Johannes Gutenberg University Mainz · DEUniversity of Basel · CHUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Regular exercise training represents an important modifier of arterial stiffness (AS). Therefore, sex-specific relations between domains of physical activity (PA; commuting, domestic, and leisure-time PA, including active sport and occupational PA) with AS were investigated. Methods and Results Stiffness index by digital photoplethysmography was investigated in 12 650 subjects from the GHS (Gutenberg Health Study). Self-reported PA was evaluated by the "Short Questionnaire to Assess Health-Enhancing Physical Activity" and reported as activity score peer week, being a combined measure of duration, frequency, and intensity of PA. Multivariable linear regression analysis demonstrated strong beneficial effects of repetitive activities, such as active commuting or leisure-time PA-related walking on AS in men, but not in women. Lower AS associated with endurance training was also found among men and premenopausal women. In contrast, intense occupational PA was related to stiffer vessels in men (

Indexed as

ExerciseHealthy LifestyleVascular StiffnessAdultCardiovascular DiseasesCross-Sectional StudiesFemaleGermanyHumansMaleMiddle AgedPhysical EnduranceProspective StudiesProtective FactorsRisk AssessmentRisk Factorsarterial compliancemortalityphysical activitypopulation basedstiffness index

Identifiers

PMID34348471
PMCPMC8475023
OpenAlexW3192892943

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.