ArticleCell reports2021
Nucleus basalis stimulation enhances working memory by stabilizing stimulus representations in primate prefrontal cortical activity.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Deep brain stimulation of the nucleus basalis of Meynert in neurodegenerative diseases with cognitive impairment: An update on evidence and mechanisms.Neural regeneration research · 2026Article
- The cost of efficiency in flexible neural representations.bioRxiv : the preprint server for biology · 2026Article
- Photomediated ion dynamics enables multi-modal learning, memory and sensing in ultralow-voltage organic electrochemical device.Nature communications · 2025Article
- Modeling visual working memory using recurrent on-center off-surround neural network with distance dependent inhibition.Scientific reports · 2025Article
- Cortical acetylcholine response to deep brain stimulation of the basal forebrain in mice.Journal of neurophysiology · 2025Article
- Basal forebrain activation improves working memory in senescent monkeys.bioRxiv : the preprint server for biology · 2024Article
- Cortical Acetylcholine Response to Deep Brain Stimulation of the Basal Forebrain.bioRxiv : the preprint server for biology · 2024Article
- Cholinergic Neuromodulation of Prefrontal Attractor Dynamics Controls Performance in Spatial Working Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neural processing in the primary auditory cortex following cholinergic lesions of the basal forebrain in ferrets.Hearing research · 2024Article
- Targeting papez circuit for cognitive dysfunction- insights into deep brain stimulation for Alzheimer's disease.Heliyon · 2024Review
- Cholinergic neuromodulation of prefrontal attractor dynamics controls performance in spatial working memory.bioRxiv : the preprint server for biology · 2024Article
- Chronic basal forebrain activation improves spatial memory, boosts neurotrophin receptor expression, and lowers BACE1 and Aβ42 levels in the cerebral cortex in mice.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Improving Visual Working Memory with Cholinergic Deep Brain Stimulation.Brain sciences · 2023Review
- Using Nonhuman Primate Models to Reverse-Engineer Prefrontal Circuit Failure Underlying Cognitive Deficits in Schizophrenia.Current topics in behavioral neurosciences · 2023Review
- Alterations of neural activity in the prefrontal cortex associated with deficits in working memory performance.Frontiers in behavioral neuroscience · 2023Review
- Protocol for behavioral and neural recording during stimulation of the macaque monkey nucleus basalis.STAR protocols · 2022Article
- Neural Mechanisms of Working Memory Accuracy Revealed by Recurrent Neural Networks.Frontiers in systems neuroscience · 2022Article
- Cholinergic Deep Brain Stimulation for Memory and Cognitive Disorders.Journal of Alzheimer's disease : JAD · 2021Review
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Acetylcholine plays a critical role in the neocortex. Cholinergic agonists and acetylcholinesterase inhibitors can enhance cognitive functioning, as does intermittent electrical stimulation of the cortical source of acetylcholine, the nucleus basalis (NB) of Meynert. Here we show in two male monkeys how NB stimulation affects working memory and alters its neural code. NB stimulation increases dorsolateral prefrontal activity during the delay period of spatial working memory tasks and broadens selectivity for stimuli but does not strengthen phasic responses to each neuron's optimal visual stimulus. Paradoxically, despite this decrease in neuronal selectivity, performance improves in many task conditions, likely indicating increased delay period stability. Performance under NB stimulation does decline if distractors similar to the target are presented, consistent with reduced prefrontal selectivity. Our results indicate that stimulation of the cholinergic forebrain increases prefrontal neural activity, and this neuromodulatory tone can improve cognitive performance, subject to a stability-accuracy tradeoff.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.