ArticleCell reports2021
FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue.
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Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Ciliopathies are responsible for short stature and insulin resistance: A systematic review of this clinical association regarding SOFT syndrome.Reviews in endocrine & metabolic disorders · 2024Pooled it
- Primary cilium as a sensory organelle and metabolic hub in health and diseases.Journal of biomedical science · 2026Review
- Primary cilia dysfunction: A critical driver of metabolic diseases (Review).International journal of molecular medicine · 2026Review
- Primary Cilia as Integrative Hubs of Metabolic Signaling in Type 2 Diabetes: Inter-Organ Evidence From Central, Peripheral, and Pancreatic Islet Tissues.Journal of cellular physiology · 2026Review
- A Ciliary Phosphoinositide Pathway Regulates the Dosage of Polycystins in Primary Cilia.Journal of the American Society of Nephrology : JASN · 2026Article
- FBF1 maintains stem cell-like properties in breast cancer via PI3K/AKT/SOX2 axis.Stem cell research & therapy · 2025Article
- Myristoylated Neuronal Calcium Sensor-1 captures the preciliary vesicle at distal appendages.eLife · 2025Article
- Distinct roles of centriole distal appendage proteins in ciliary assembly and disassembly.Cell communication and signaling : CCS · 2024Article
- Transiently formed nucleus-to-cilium microtubule arrays mediate senescence initiation in a KIFC3-dependent manner.Nature communications · 2024Article
- Aging and homeostasis of the hypodermis in the age-related deterioration of skin function.Cell death & disease · 2024Review
- Exercise AltersMicroRNA (Shariqah, United Arab Emirates) · 2024Article
- Genome-wide unraveling SNP pairwise epistatic effects associated with sheep body weight.Animal biotechnology · 2023Article
- A stress-induced cilium-to-PML-NB route drives senescence initiation.Nature communications · 2023Article
- Myristoylated Neuronal Calcium Sensor-1 captures the ciliary vesicle at distal appendages.bioRxiv : the preprint server for biology · 2023Article
- Obesity, Weight Loss, Lifestyle Interventions, and Autosomal Dominant Polycystic Kidney Disease.Kidney and dialysis · 2022Article
- Ciliary control of adipocyte progenitor cell fate regulates energy storage.Frontiers in cell and developmental biology · 2022Review
- Autophagy and the primary cilium in cell metabolism: What's upstream?Frontiers in cell and developmental biology · 2022Review
- Tissue-specific requirement of sodium channel and clathrin linker 1 (Sclt1) for ciliogenesis during limb development.Frontiers in cell and developmental biology · 2022Article
- Mouse model of the adipose organ: the heterogeneous anatomical characteristics.Archives of pharmacal research · 2021Review
- Primary Cilia Are Critical Regulators of White Adipose Tissue Expansion.Frontiers in physiology · 2021Review
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 2 countries.
Yingyi ZhangDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Jielu HaoDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Mariana G TarragoMayo Clinic Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Gina M WarnerMayo Clinic Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Nino GiorgadzeMayo Clinic Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Qing WeiDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA; Center for Energy Metabolism and Reproduction, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen 518055, China.
Yan HuangDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Kai HeDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Chuan ChenDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Thais R PeclatMayo Clinic Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Thomas A WhiteMayo Clinic Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Kun LingDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Tamar TchkoniaMayo Clinic Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
James L KirklandMayo Clinic Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Eduardo N ChiniMayo Clinic Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Jinghua HuDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA; Mayo Clinic Robert M. and Billie Kelley Pirnie Translational Polycystic Kidney Disease Center, Mayo Clinic, Rochester, MN, USA. Electronic address: hu.jinghua@mayo.edu.
Mayo Clinic in Arizona · USMayo Clinic in Florida · US
Funding
Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, Nathan K LeBrasseur · 2019 to 2026
$28.7MPilot and FeasibilityP30DK090728 · NIDDK · MAYO CLINIC ROCHESTER · PI TORRES, VICENTE E · 2010 to 2019
$11.8MEffect of Aging on Preadipocyte DifferentiationR37AG013925 · NIA · MAYO CLINIC ROCHESTER · PI KIRKLAND, JAMES L. · 2016 to 2025
$6.6MTranslational Geroscience NetworkR33AG061456 · NIA · MAYO CLINIC ROCHESTER · PI JAMES L. KIRKLAND, STEPHEN B. KRITCHEVSKY · 2019 to 2026
$6.2MMolecular dissection of the ciliary gateR01DK099160 · NIDDK · MAYO CLINIC ROCHESTER · PI Jinghua Hu · 2014 to 2026
$4.0MExploration of the functions of the ciliopathy Arls in cilia.R01DK090038 · NIDDK · MAYO CLINIC ROCHESTER · PI HU, JINGHUA · 2011 to 2019
$3.1MRole of CD38 in NAD metabolism: from the basic biology of aging to translationR01AG058812 · NIA · MAYO CLINIC ROCHESTER · PI CHINI, EDUARDO N · 2018 to 2022
$2.0MA novel cilium-to-nucleus axis promotes cellular senescenceR01AG076469 · NIA · MAYO CLINIC ROCHESTER · PI Jinghua Hu · 2022 to 2026
$1.6MNIA NIH HHS P01 AG062413NIA NIH HHS R01 AG058812NIA NIH HHS R01 AG076469NIA NIH HHS R33 AG061456NIA NIH HHS R37 AG013925NIDDK NIH HHS P30 DK090728NIDDK NIH HHS R01 DK090038NIDDK NIH HHS R01 DK099160
Abstract
Preadipocytes dynamically produce sensory cilia. However, the role of primary cilia in preadipocyte differentiation and adipose homeostasis remains poorly understood. We previously identified transition fiber component FBF1 as an essential player in controlling selective cilia import. Here, we establish Fbf1
Indexed as
3T3-L1 CellsAdaptor Proteins, Signal TransducingAdipocytesAdipogenesisAdipose Tissue, BeigeAdipose Tissue, WhiteAnimalsCell RespirationCiliaCyclic AMP-Dependent Protein KinasesFemaleFibroblastsHedgehog ProteinsHomozygoteHumansHyperphagiaAdaptor Proteins, Signal TransducingBbs1 protein, mouseCyclic AMP-Dependent Protein KinasesFBF1 protein, humanFbf1 protein, mouseHedgehog ProteinsMicrotubule-Associated ProteinsTranscription FactorsadipogenesisBBSbeigingdiabetesFBF1healthy obesityHedgehogPKApreadipocyteprimary cilia
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.