Evidence map›Paper›PMID 34348123›Full record

ArticleUrology2022

Demographic Differences and Disparities in the Misdiagnosis of Interstitial Cystitis/Bladder Pain Syndrome in a National Cohort of VA Patients.

Kai B Dallas, Catherine Bresee, Amanda De Hoedt, Justin F Senechal, Kamil E Barbour, Jayoung Kim, Stephen J Freedland, Jennifer T Anger

Open access · greenAbstract read
In one paragraph

Article in Urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Excluding confusable diseases in patients with presumptive diagnosis of interstitial cystitis: A large patient cohort study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kai B DallasDepartment of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, CA. Electronic address: kai.dallas@cshs.edu.
Catherine BreseeDepartment of Biostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Amanda De HoedtVeterans Affairs Medical Centers, Urology Section, Durham, NC.
Justin F SenechalVeterans Affairs Medical Centers, Urology Section, Durham, NC.
Kamil E BarbourNational Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, GA.
Jayoung KimDepartment of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, CA.
Stephen J FreedlandDepartment of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, CA.
Jennifer T AngerDepartment of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, CA.
Cedars-Sinai Medical Center · USNational Center for Chronic Disease Prevention and Health Promotion · US

Funding

The Epidemiology of Interstitial Cystitis in a Nationwide Multiethnic VA CohortU01DP006079 · DP · CEDARS-SINAI MEDICAL CENTER · PI ANGER, JENNIFER TASH, FREEDLAND, STEPHEN JAY · 2015 to 2019
$3.8M
NCCDPHP CDC HHS U01 DP006079
6 · The paper itself

Abstract

objectiveTo explore association between misdiagnosis of IC/BPS and demographics. Interstitial cystitis/bladder pain syndrome (IC/BPS) is associated with significant diagnostic uncertainty, resulting in frequent misdiagnosis as there is little known about the potential impact of key demographic factors.

methodsAll patients in the VA system between 1999-2016 were identified by ICD-9/10 codes for IC/BPS (595.1/N30.10) (n = 9,503). ICD code accuracy for true IC/BPS (by strict criteria) was assessed by in-depth chart abstraction (n = 2,400). Associations were explored between rates of misdiagnosis and demographics.

resultsIC/BPS criteria were met in only 651 (48.8%) of the 1,334 charts with an ICD code for IC/BPS reviewed in depth. There were no differences in the misdiagnosis rate by race (P=.27) or by ethnicity (P=.97), after adjusting for differences in age and gender. In IC/BPS-confirmed cases, female patients were diagnosed at a younger age than males (41.9 vs. 58.2 years, P<.001). Black and Hispanic patients were diagnosed at a younger age compared to White (41.9 vs. 50.2 years, P<.001) and non-Hispanic patients, respectively (41.1 vs. 49.1 years, P=.002).

conclusionThere was a high rate of misdiagnosis of IC/BPS overall, with only 48.8% of patients with an ICD code for IC/BPS meeting diagnostic criteria. There were no significant associations between diagnostic accuracy and race/ethnicity. Black and Hispanic patients were more likely to receive a diagnosis of IC/BPS at a younger age, suggesting there may be differing natural histories or presentation patterns of IC/BPS between racial/ethnic groups.

Indexed as

Cystitis, InterstitialCohort StudiesDemographyDiagnostic ErrorsFemaleHumansMale

Identifiers

PMID34348123
PMCPMC10461430
OpenAlexW3192644050

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.