ArticleImmunity2021
Environmental enteric dysfunction induces regulatory T cells that inhibit local CD4+ T cell responses and impair oral vaccine efficacy.
Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07626606 (Temporal and Spatial Immune Profiling of Oral Rotavirus Vaccine Responses in Zambian Adults With Environmental Enteropathy), which is not on this map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Temporal and Spatial Immune Profiling of Oral Rotavirus Vaccine Responses in Zambian Adults With Environmental Enteropathy
Who cites it
38 citing papers in PubMed, 69 citations in OpenAlex.
- Longitudinal Analysis of the Intestinal Microbiota among a Cohort of Children in Rural and Urban Areas of Pakistan.Nutrients · 2023Trial
- Bile Acid Profiling Reveals Distinct Signatures in Undernourished Children with Environmental Enteric Dysfunction.The Journal of nutrition · 2021Trial
- Nanomaterial-based vaccines: An advanced approach against rotavirus: A review article.Human vaccines & immunotherapeutics · 2026Review
- Mucosal immunity: mechanism and application in cancer immunotherapy.Journal of hematology & oncology · 2026Review
- Article
- Enteropathy produced in mice by intergenerational transmission of small intestinal microbiota from undernourished children.Nature microbiology · 2026Article
- A Double-Edged Sword: Breast Milk-Derived Maternal Antibodies and Infant Vaccine Responses: A Narrative Review.Vaccines · 2026Review
- Rotavirus mucosal immunology: insights and research priorities from an international convening in Liverpool, March 2024.NPJ vaccines · 2026Article
- Peripheral rotavirus-specific T-cell responses following monovalent oral rotavirus vaccine in infants.NPJ vaccines · 2026Article
- Striking a balance: how the gut microbiome shapes the fate of intestinal CD4+ T cells.Discovery immunology · 2026Review
- Disrupting the vicious cycle of malnutrition and enteropathy: advancing strategies to improve child physical and neurocognitive outcomes.Frontiers in public health · 2026Review
- Effects of intergenerational transmission of small intestinal bacteria cultured from stunted Bangladeshi children with enteropathy.bioRxiv : the preprint server for biology · 2025Article
- Article
- Malnutrition drives infection susceptibility and dysregulated myelopoiesis that persists after refeeding intervention.bioRxiv : the preprint server for biology · 2025Article
- Intestinal microbiome changes in response to amino acid and micronutrient supplementation: secondary analysis of the AMAZE trial.Gut microbiome (Cambridge, England) · 2025Article
- Tissue-specific roles of regulatory T cells: mechanisms of suppression and beyond along with emerging therapeutic insights in autoimmune indications.Frontiers in immunology · 2025Review
- The epidemiology and impact of persistentEClinicalMedicine · 2024Article
- LAMTOR1 decreased exosomal PD-L1 to enhance immunotherapy efficacy in non-small cell lung cancer.Molecular cancer · 2024Article
- Regulatory T cells in the context: deciphering the dynamic interplay with the tissue environment.Current opinion in immunology · 2024Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 2 countries.
Amrita BhattacharjeeR.K. Mellon Institute for Pediatric Research, Pediatrics Department, Infectious Disease Section, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224 USA.
Ansen H P BurrR.K. Mellon Institute for Pediatric Research, Pediatrics Department, Infectious Disease Section, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224 USA; Program in Microbiology and Immunology, Department of Immunology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, USA.
Abigail E Overacre-DelgoffeR.K. Mellon Institute for Pediatric Research, Pediatrics Department, Infectious Disease Section, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224 USA.
Justin T TometichR.K. Mellon Institute for Pediatric Research, Pediatrics Department, Infectious Disease Section, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224 USA.
Deyi YangR.K. Mellon Institute for Pediatric Research, Pediatrics Department, Infectious Disease Section, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224 USA; Central South University, Xiangya School of Medicine, Changsha, PRC.
Brydie R HuckesteinProgram in Microbiology and Immunology, Department of Immunology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, USA.
Jonathan L LinehanMetaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Sean P SpencerMetaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Jason A HallMetaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Oliver J HarrisonMetaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Denise Morais da FonsecaMetaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Elizabeth B NortonDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
Yasmine BelkaidMetaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Timothy W HandR.K. Mellon Institute for Pediatric Research, Pediatrics Department, Infectious Disease Section, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224 USA; Program in Microbiology and Immunology, Department of Immunology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, USA. Electronic address: timothy.hand@chp.edu.
National Institutes of Health · USUniversity of Pittsburgh · USChildren's Hospital of Pittsburgh · USNational Institute of Allergy and Infectious Diseases · USTulane University · US
Funding
NIAID Microbiome ProgramZICAI001233 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MOUTSOPOULOS, NIKI · 2018 to 2025
$18.9MAutoimmunity and Immunopathology Training ProgramT32AI089443 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHLOMCHIK, MARK J · 2010 to 2024
$6.6MRole of Tissue-Specific Factors in the Control of ImmunityZIAAI001132 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BELKAID, YASMINE · 2011 to 2025
$6.4MDefining the role of the mucosal immune response and microbiota in enteropathy-driven oral vaccine failureR21AI142051 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HAND, TIMOTHY WESLEY · 2019 to 2020
$412kRegulation of commensal-specific T cells during gastrointestinal inflammationK22AI108719 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HAND, TIMOTHY WESLEY · 2015 to 2016
$270kMechanisms of dmLT AdjuvantR56AI143937 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI NORTON, ELIZABETH B · 2020 to 2020
$261kNIAID NIH HHS K22 AI108719NIAID NIH HHS R21 AI142051NIAID NIH HHS R56 AI143937NIAID NIH HHS T32 AI089443
Abstract
Environmental enteric dysfunction (EED) is a gastrointestinal inflammatory disease caused by malnutrition and chronic infection. EED is associated with stunting in children and reduced efficacy of oral vaccines. To study the mechanisms of oral vaccine failure during EED, we developed a microbiota- and diet-dependent mouse EED model. Analysis of E. coli-labile toxin vaccine-specific CD4
Indexed as
Administration, OralAnimalsBacterial ToxinsCell LineDisease Models, AnimalDrosophilaEscherichia coliEscherichia coli VaccinesFemaleForkhead Transcription FactorsGastrointestinal DiseasesIntestine, SmallMaleMiceMice, Inbred C57BLMice, TransgenicBacterial ToxinsEscherichia coli VaccinesForkhead Transcription FactorsFoxp3 protein, mouseNuclear Receptor Subfamily 1, Group F, Member 3AIECdietE coliEEDintestinalmicrobiotaoral vaccinationRORgt TregstuntingTregs
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT07626606ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.