Evidence map›Paper›PMID 34348116›Full record

ArticleThe Journal of infection2021

Transmission of SARS-CoV-2 in the household setting: A prospective cohort study in children and adults in England.

Elizabeth Miller, Pauline A Waight, Nick J Andrews, Kelsey McOwat, Kevin E Brown, Katja Höschler, Samreen Ijaz, Louise Letley, Donna Haskins, Mary Sinnathamby and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 5 pooled it
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. The role of children in transmission of SARS-CoV-2 variants of concern within households: an updated systematic review and meta-analysis, as at 30 June 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Pooled it
  3. Pooled it
  4. The role of children in household transmission of COVID-19: a systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Elizabeth MillerPHE Immunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, NW9 5EQ London, United Kingdom. Electronic address: liz.miller@phe.gov.uk.
Pauline A WaightPHE Immunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, NW9 5EQ London, United Kingdom. Electronic address: pauline.kaye@phe.gov.uk.
Nick J AndrewsData and Analytical Sciences, Public Health England, 61 Colindale Avenue, NW9 5EQ London, United Kingdom. Electronic address: nick.andrews@phe.gov.uk.
Kelsey McOwatPHE Immunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, NW9 5EQ London, United Kingdom. Electronic address: kelsey.mcowat@phe.gov.uk.
Kevin E BrownPHE Immunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, NW9 5EQ London, United Kingdom. Electronic address: kevin.brown@phe.gov.uk.
Katja HöschlerNational Infection Services Laboratories, Public Health England, 61 Colindale Avenue, NW9 5EQ London, United Kingdom. Electronic address: Katja.hoschler@phe.gov.uk.
Samreen IjazNational Infection Services Laboratories, Public Health England, 61 Colindale Avenue, NW9 5EQ London, United Kingdom. Electronic address: samreen.ijaz@phe.gov.uk.
Louise LetleyPHE Immunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, NW9 5EQ London, United Kingdom. Electronic address: louise.letley@phe.gov.uk.
Donna HaskinsPHE Immunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, NW9 5EQ London, United Kingdom. Electronic address: donna.haskins@phe.gov.uk.
Mary SinnathambyPHE Immunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, NW9 5EQ London, United Kingdom. Electronic address: mary.sinnathamby@phe.gov.uk.
Hannah CuthbertsonImmunoassay Laboratory,  National Infection Service, Public Health England, Porton Down SP4 0JG, United Kingdom. Electronic address: hannah.cutherbertson@phe.gov.uk.
Bassam HallisImmunoassay Laboratory,  National Infection Service, Public Health England, Porton Down SP4 0JG, United Kingdom. Electronic address: bassan.hallis@phe.gov.uk.
Vaishnavi ParimalanathanNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG United Kingdom  and  Royal College of General Practitioners Research and Surveillance Centre, Euston Square, London NW1 2FB, United Kingdom. Electronic address: vp16@utas.edu.au.
Simon de LusignanNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG United Kingdom  and  Royal College of General Practitioners Research and Surveillance Centre, Euston Square, London NW1 2FB, United Kingdom. Electronic address: simon.delusignan@phc.ox.ac.uk.
Jamie Lopez-BernalPHE Immunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, NW9 5EQ London, United Kingdom. Electronic address: Jamie.LopezBernal2@phe.gov.uk.
Public Health England · GBRoyal College of General Practitioners · GBUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo measure secondary attack rates (SARs) in prospectively followed household contacts of paediatric and adult cases of SARS-CoV-2 infection in England.

methodsSelf-taken nasal swabs from household contacts of PCR confirmed cases of COVID-19  and blood samples  on day 35 were tested for evidence of infection with SARS-CoV-2 virus.

resultsThe secondary attack rate (SAR) among 431 contacts of 172 symptomatic index cases  was 33% (95% confidence intervals [CI] 25-40) and was lower from primary cases without respiratory symptoms, 6% (CI 0-14) vs 37% (CI 29-45), p = 0.030. The SAR from index cases <11 years  was  25% (CI 12-38). SARs ranged from 16% (4-28) in contacts <11 years old to 36% (CI 28-45) in contacts aged 19-54 years (p = 0.119). The proportion infected who developed symptoms (78%) was similar by age (p = 0.44) though <19 year olds had fewer mean number of symptoms than adults (p = 0.001) and fewer reported loss of sense of taste or smell (p = 0.0001).

conclusionsThere are high risks of  transmission of SARS-CoV-2 virus in the home, including those where infection is introduced by a child. The risk of children acquiring infection was lower than that in adults and fewer developed typical symptoms of Covid-19 infection.

Indexed as

COVID-19SARS-CoV-2AdultChildFamily CharacteristicsHumansIncidenceProspective StudiesHouseholdsSARS-CoV-2 transmissionSecondary attack rates by age

Identifiers

PMID34348116
PMCPMC8325949
OpenAlexW3193147686

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.