Evidence map›Paper›PMID 34347822›Full record

ArticlePloS one2021

Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population.

Youhei Yamada, Haruki Nakamura, Hiromasa Tsujiguchi, Akinori Hara, Sakae Miyagi, Takayuki Kannon, Takehiro Sato, Kazuyoshi Hosomichi, Thao Thi Thu Nguyen, Yasuhiro Kambayashi and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Youhei YamadaDepartment of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.ORCID 0000-0003-1706-3465
Haruki NakamuraDepartment of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Hiromasa TsujiguchiDepartment of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Akinori HaraDepartment of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Sakae MiyagiInnovative Clinical Research Center, Kanazawa University, Kanazawa, Japan.
Takayuki KannonAdvanced Preventive Medical Sciences Research Center, Kanazawa University, Kanazawa, Japan.
Takehiro SatoAdvanced Preventive Medical Sciences Research Center, Kanazawa University, Kanazawa, Japan.ORCID 0000-0001-9866-0346
Kazuyoshi HosomichiAdvanced Preventive Medical Sciences Research Center, Kanazawa University, Kanazawa, Japan.
Thao Thi Thu NguyenFaculty of Public Health, Haiphong University of Medicine and Pharmacy, Haiphong, Vietnam.
Yasuhiro KambayashiDepartment of Public Health, Faculty of Veterinary Medicine, Okayama University of Science, Kanazawa, Japan.
Yukari ShimizuFaculty of Health Sciences, Department of Nursing, Komatsu University, Kanazawa, Japan.
Kim Oanh PhamDepartment of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Keita SuzukiDepartment of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Fumihiko SuzukiDepartment of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Tomoko KasaharaDepartment of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Hirohito TsuboiInstitute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.ORCID 0000-0001-5986-8523
Atsushi TajimaAdvanced Preventive Medical Sciences Research Center, Kanazawa University, Kanazawa, Japan.ORCID 0000-0001-6808-5491
Hiroyuki NakamuraDepartment of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Kanazawa University · JPHai Phong University of Management and Technology · VNKomatsu University · JPOkayama University of Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A polymorphism in the ADRB3 gene (Trp64Arg) has been associated with obesity, insulin resistance, and hypertension. This cross-sectional study investigated the relationships among this polymorphism, hypertension, and insulin resistance values (HOMA-IR) in 719 Japanese subjects aged 40 years and older. The genotype frequencies of Trp64Trp (homozygous, wild), Trp64Arg (heterozygous, variant), and Arg64Arg (homozygous, variant) were 466 (65%), 233 (32%), and 20 (3%), respectively. Insulin resistance was associated with an increased risk of hypertension in a Japanese population. This relationship was dependent on the presence or absence of the Trp64Arg polymorphism (odds ratio, 2.054; confidence interval, 1.191 to 3.541; P value, 0.010). Therefore, the Trp64Arg polymorphism of ADRB3 was associated with hypertension and insulin resistance in a healthy Japanese population. This relationship, which was dependent on the polymorphism, may predict the development of hypertension and diabetes.

Indexed as

HypertensionInsulin ResistanceReceptors, Adrenergic, beta-3AdultAgedAsian PeopleCross-Sectional StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansJapanMaleMiddle AgedPolymorphism, Single NucleotideADRB3 protein, humanReceptors, Adrenergic, beta-3

Identifiers

PMID34347822
PMCPMC8336805
OpenAlexW3193149908

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.