Evidence map›Paper›PMID 34347725›Full record

Observational studyPancreas2021

The Association of Smoking and Alcohol Abuse on Anxiety and Depression in Patients With Recurrent Acute or Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation: A Report From the Prospective Observational Study of TPIAT Cohort.

Luis F Lara, Solvejg Wastvedt, James S Hodges, Piotr Witkowski, Martin Wijkstrom, R Matthew Walsh, Vikesh K Singh, Sarah J Schwarzenberg, Timothy L Pruett, Andrew Posselt and 15 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pancreas, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Risk Factors for Addictive Behaviors: A General Overview.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 14 institutions in 1 country.

Luis F LaraFrom the Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.
Solvejg WastvedtSchool of Public Health, University of Minnesota, Minneapolis, MN.
James S HodgesSchool of Public Health, University of Minnesota, Minneapolis, MN.
Piotr WitkowskiDepartment of Surgery, University of Chicago, Chicago, IL.
Martin WijkstromDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
R Matthew WalshDepartment of General Surgery, Cleveland Clinic, Cleveland, OH.
Vikesh K SinghDivision of Gastroenterology, Department of Medicine, John Hopkins Medical Institutions, Baltimore, MD.
Sarah J SchwarzenbergDepartment of Pediatrics.
Timothy L PruettDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN.
Andrew PosseltDepartment of Surgery, University of California San Francisco, San Francisco, CA.
Bashoo NaziruddinDepartment of Surgery, Islet Cell Processing Laboratory, Baylor Health, Dallas, TX.
Jaimie D Nathan
Katherine A MorganDivision of GI and Laparoscopic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC.
Rebecca MitchellSchool of Public Health, University of Minnesota, Minneapolis, MN.
Varvara A KirchnerDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN.
SriPrakash L MokshagundamDepartment of Medicine, University of Louisville, Louisville, KY.
Betul HatipogluDepartment of Medicine, Division of Clinical and Molecular Endocrinology, University Hospitals, Cleveland, OH.
Timothy B GardnerDepartment of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Martin L FreemanDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN.
Srinath ChinnakotlaDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN.
Gregory J BeilmanDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN.
Maisam Abu-El-Haija
Darwin L ConwellFrom the Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.
Melena D BellinDivision of Pediatric Endocrinology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN.
POST study consortium
University of Minnesota Medical Center · USUniversity of Minnesota · USCincinnati Children's Hospital Medical Center · USThe Ohio State University Wexner Medical Center · USBaylor Scott & White Health · USCleveland Clinic · USDartmouth–Hitchcock Medical Center · USJohns Hopkins University · USMedical University of South Carolina · USUniversity Hospitals of Cleveland · USUniversity of California, San Francisco · USUniversity of Chicago · USUniversity of Louisville · USUniversity of Pittsburgh Medical Center · US

Funding

Advancing Treatment for Pancreatitis: A Prospective Observational Study of TPIATR01DK109124 · NIDDK · UNIVERSITY OF MINNESOTA · PI BELLIN, MELENA D. · 2016 to 2021
$4.0M
NIDDK NIH HHS R01 DK109124
6 · The paper itself

Abstract

objectivesSmoking and alcohol use are risk factors for acute and chronic pancreatitis, and their role on anxiety, depression, and opioid use in patients who undergo total pancreatectomy and islet autotransplantation (TPIAT) is unknown.

methodsWe included adults enrolled in the Prospective Observational Study of TPIAT (POST). Measured variables included smoking (never, former, current) and alcohol abuse or dependency history (yes vs no). Using univariable and multivariable analyses, we investigated the association of smoking and alcohol dependency history with anxiety and depression, opioid use, and postsurgical outcomes.

resultsOf 195 adults studied, 25 were current smokers and 77 former smokers, whereas 18 had a history of alcohol dependency (of whom 10 were current smokers). A diagnosis of anxiety was associated with current smoking (P = 0.005), and depression was associated with history of alcohol abuse/dependency (P = 0.0001). However, active symptoms of anxiety and depression at the time of TPIAT were not associated with smoking or alcohol status. Opioid use in the past 14 days was associated with being a former smoker (P = 0.005).

conclusionsActive smoking and alcohol abuse history were associated with a diagnosis of anxiety and depression, respectively; however, at the time of TPIAT, symptom scores suggested that they were being addressed.

Indexed as

Acute DiseaseAdultAlcoholismAnxietyCohort StudiesDepressionFemaleHumansIslets of Langerhans TransplantationLogistic ModelsMaleMiddle AgedPancreatectomyPancreatitisPancreatitis, ChronicRecurrence

Identifiers

PMID34347725
PMCPMC8373657
OpenAlexW3188865548

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.