Evidence map›Paper›PMID 34347577›Full record

ArticlemAbs

Targeting and pharmacology of an anti-IL13Rα2 antibody and antibody-drug conjugate in a melanoma xenograft model.

Parul Gupta, Ziyue Karen Jiang, Bing Yang, Lisa Manzuk, Edward Rosfjord, Johnny Yao, Luanna Lemon, Kavon Noorbehesht, John David, Sujiet Puthenveetil and 6 more

Open access · goldAbstract readVideo-Audio Media
In one paragraph

Article in mAbs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. IL13Rα2-Targeting Antibodies for Immuno-PET in Solid Malignancies.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Parul GuptaGlobal Science & Technology - Comparative Medicine, Pfizer Inc., San Diego, CA, USA.
Ziyue Karen JiangGlobal Science & Technology - Comparative Medicine, Pfizer Inc., San Diego, CA, USA.
Bing YangGlobal Science & Technology - Comparative Medicine, Pfizer Inc., San Diego, CA, USA.
Lisa ManzukGlobal Science & Technology - Comparative Medicine, Pfizer Inc., San Diego, CA, USA.
Edward RosfjordOncology Research and Development, Pfizer Inc., Pearl River, NY, USA.
Johnny YaoOncology Research and Development, Pfizer Inc., Pearl River, NY, USA.
Luanna LemonOncology Research and Development, Pfizer Inc., Pearl River, NY, USA.
Kavon NoorbeheshtGlobal Science & Technology - Comparative Medicine, Pfizer Inc., San Diego, CA, USA.
John DavidGlobal Science & Technology - Comparative Medicine, Pfizer Inc., San Diego, CA, USA.
Sujiet PuthenveetilMedicinal Sciences, Pfizer Incorporated, San Diego, CA, USA.
Jeffrey M CasavantMedicinal Sciences, Pfizer Incorporated, San Diego, CA, USA.
Elwira MuszynskaOncology Research and Development, Pfizer Inc., Pearl River, NY, USA.
Fengping LiBiomedicine Design, Pfizer Inc., San Diego, CA, USA.
Mauricio LealBiomedicine Design, Pfizer Inc., San Diego, CA, USA.
Puja SapraOncology Research and Development, Pfizer Inc., Pearl River, NY, USA.
Anand GiddabasappaGlobal Science & Technology - Comparative Medicine, Pfizer Inc., San Diego, CA, USA.ORCID 0000-0002-1546-2481
Pfizer (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IL13Rα2 is a cell surface tumor antigen that is overexpressed in multiple tumor types. Here, we studied biodistribution and targeting potential of an anti-IL13Rα2 antibody (Ab) and anti-tumor activity of anti-IL13Rα2-antibody-drug conjugate (ADC). The anti-IL13Rα2 Ab was labeled with fluorophore AF680 or radioisotope

Indexed as

AminobenzoatesAntineoplastic Agents, ImmunologicalImmunoconjugatesInterleukin-13 Receptor alpha2 SubunitMelanoma, ExperimentalNeoplasm ProteinsOligopeptidesAnimalsCell Line, TumorHumansMiceMice, NudeXenograft Model Antitumor AssaysAminobenzoatesAntineoplastic Agents, ImmunologicalauristatinIL13RA2 protein, humanImmunoconjugatesInterleukin-13 Receptor alpha2 SubunitNeoplasm ProteinsOligopeptidesAntibody drug conjugatecancerefficacyfluorescence molecular tomographyIL13rα2imagingpharmacokineticspositron emission tomographytumor targeting

Identifiers

PMID34347577
PMCPMC8344738
OpenAlexW3188189762

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.