Evidence map›Paper›PMID 34347519›Full record

ArticleApplied and environmental microbiology2021

Enzymatic Synthesis of l-

Ryotaro Hara, Yuta Nakajima, Hiroaki Yanagawa, Ryo Gawasawa, Izumi Hirasawa, Kuniki Kino

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ryotaro HaraResearch Institute for Science and Engineering, Waseda Universitygrid.5290.e, Tokyo, Japan.ORCID 0000-0003-0553-3837
Yuta NakajimaDepartment of Applied Chemistry, Faculty of Science and Engineering, Waseda Universitygrid.5290.e, Tokyo, Japan.
Hiroaki YanagawaDepartment of Applied Chemistry, Faculty of Science and Engineering, Waseda Universitygrid.5290.e, Tokyo, Japan.
Ryo GawasawaDepartment of Applied Chemistry, Faculty of Science and Engineering, Waseda Universitygrid.5290.e, Tokyo, Japan.
Izumi HirasawaDepartment of Applied Chemistry, Faculty of Science and Engineering, Waseda Universitygrid.5290.e, Tokyo, Japan.
Kuniki KinoResearch Institute for Science and Engineering, Waseda Universitygrid.5290.e, Tokyo, Japan.ORCID 0000-0003-2367-3876
Waseda University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β-Hydroxy-α-amino acids are useful compounds for pharmaceutical development. Enzymatic synthesis of β-hydroxy-α-amino acids has attracted considerable interest as a selective, sustainable, and environmentally benign process. In this study, we identified a novel amino acid hydroxylase, AEP14369, from Sulfobacillus thermotolerans Y0017, which is included in a previously constructed CAS-like superfamily protein library, to widen the variety of amino acid hydroxylases. The detailed structures determined by nuclear magnetic resonance and X-ray crystallography analysis of the enzymatically produced compounds revealed that AEP14369 catalyzed

Indexed as

Bacterial ProteinsEscherichia coliEubacterialesGlycineHistidineHydroxylationKetoglutaric AcidsMixed Function OxygenasesBacterial ProteinsGlycineHistidineKetoglutaric AcidsMixed Function Oxygenases2-oxoglutarate-dependent hydroxylaseasymmetric hydroxylationCAS-like superfamilydioxygenasesl-threo-β-hydroxy-Glnl-threo-β-hydroxy-Hisβ-hydroxy-α-amino acid

Identifiers

PMID34347519
PMCPMC8478450
OpenAlexW3187467474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.